Measuring T2 in vivo with J-difference editing: application to GABA at 3 Tesla.
Measuring T2 in vivo with J-difference editing: application to GABA at 3 Tesla.
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DOI：
10.1002/jmri.22865
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发表时间：
2012-01
影响因子：
4.4
通讯作者：
Barker, Peter B.
中科院分区：
文献类型：
--
作者：
Edden, Richard A. E.;Intrapiromkul, Jarunee;Zhu, He;Cheng, Ying;Barker, Peter B.
建立一种无需模拟即可通过光谱编辑检测到的代谢物体内横向弛豫速率(T2)的实验方法，并证明该方法可用于测量γ-氨基丁酸的T2。所提出的方法首先使用在纯模体溶液(10 mMγ-氨基丁酸)中的测量来确定编辑信号的TE依赖性；还确定了模体T2。一旦知道编辑回波时间(TE)调制模式，就可以使用它来确定体内的T2。用J-Difference编辑法对5名健康成人在3T时枕叶GABA T2进行了测量。我们还测量了GABA信号中不需要的大分子成分。编辑的GABA信号的体内T2为88±12毫秒；这一初步结果比文献中在该场强下的其他代谢物T2值略短。目前，光谱编辑方法被广泛用于检测低浓度的代谢物，如GABA，但至今还没有人提出测量横向弛豫时间(T2)的编辑采集方法。该方法已成功地用于测定GABA的T2。
To develop an experimental approach for determining in vivo transverse relaxation rates (T2) of metabolites that are detected by spectral editing without using simulations, and to demonstrate this approach to measure the T2 of γ-aminobutyric acid (GABA). The proposed method first determines the TE-dependence of the edited signals using measurements in a pure phantom solution (10 mM γ-aminobutyric acid; GABA); the phantom T2 is also determined. Once the editing echo time (TE) -modulation pattern is known, it can then be used to determine T2 in vivo. The method was applied to measure GABA T2 in the occipital lobe of five healthy adult subjects at 3T, using a J-difference editing method. Unwanted macromolecular contributions to the GABA signal were also measured. The in vivo T2 of edited GABA signal was 88 ± 12 ms; this preliminary result is somewhat shorter than other metabolite T2 values in the literature at this field strength. Spectral editing methods are now widely used to detect low concentration metabolites, such as GABA, but to date no edited acquisition methods have been proposed for the measurement of transverse relaxation times (T2). The method described has been successfully applied to measuring the T2 of GABA.
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影响因子：
4.4
作者：
Träber, F;Block, W;Schild, HH
通讯作者：
Schild, HH
DOI：
10.1016/j.cub.2010.09.003
发表时间：
2010-10-12
期刊：
Current biology : CB
影响因子：
--
作者：
Boy F;Evans CJ;Edden RA;Singh KD;Husain M;Sumner P
通讯作者：
Sumner P
DOI：
10.1523/jneurosci.6158-09.2010
发表时间：
2010-03-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Yoon JH;Maddock RJ;Rokem A;Silver MA;Minzenberg MJ;Ragland JD;Carter CS
通讯作者：
Carter CS
影响因子：
3.3
作者：
Zaaraoui, Wafaa;Fleysher, Lazar;Gonen, Oded
通讯作者：
Gonen, Oded
DOI：
10.1073/pnas.0900728106
发表时间：
2009-05-19
影响因子：
11.1
作者：
Muthukumaraswamy, Suresh D.;Edden, Richard A. E.;Singh, Krish D.
通讯作者：
Singh, Krish D.