Motor Error in Parietal Area 5 and Target Error in Area 7 Drive Distinctive Adaptation in Reaching
Motor Error in Parietal Area 5 and Target Error in Area 7 Drive Distinctive Adaptation in Reaching
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DOI：
10.1016/j.cub.2018.05.056
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发表时间：
2018-07-23
期刊：
影响因子：
9.2
通讯作者：
Kitazawa, Shigeru
中科院分区：
文献类型：
--
作者：
Inoue, Masato;Kitazawa, Shigeru
到达误差时驱动逐次自适应以补偿误差。顶叶关联区与错误编码有关，但顶叶错误信号是否直接驱动适应尚不清楚。我们首先检测了5区和7区神经元的活动，同时两只猴子进行快速目标到达，以阐明顶叶错误信号是否以及如何驱动适应到达。我们引入随机误差使用电机驱动的棱镜装置，以增加随机电机误差到达。这两个区域的神经元都编码了到达目标位置之前的信息和到达目标位置之后的运动误差信息。然而，运动后微刺激导致了一次又一次的适应，只有当它被传递到第5区域时才会消除运动误差。相比之下，对区域7的刺激引起了一次又一次的适应，从而使到达的端点向目标位置调整。我们进一步假设7区编码了在到达过程中由目标跳跃引起的目标误差，我们的结果支持了这一假设。7区神经元编码目标错误信息，而5区神经元不编码目标错误信息。这些结果表明，5区提供适应运动误差的信号，7区提供适应目标误差的信号。
Errors in reaching drive trial-by-trial adaptation to compensate for the error. Parietal association areas are implicated in error coding, but whether the parietal error signals directly drive adaptation remains unknown. We first examined the activity of neurons in areas 5 and 7 while two monkeys performed rapid target reaching to clarify whether and how the parietal error signals drive adaptation in reaching. We introduced random errors using a motor-driven prism device to augment random motor errors in reaching. Neurons in both regions encoded information on the target position prior to reaching and information on the motor error after reaching. However, post-movement microstimulation caused trial-by-trial adaptation to cancel the motor error only when it was delivered to area 5. By contrast, stimulation to area 7 caused trial-by-trial adaptation so that the reaching endpoint was adjusted toward the target position. We further hypothesized that area 7 would encode target error that is caused by a target jump during the reach, and our results support this hypothesis. Area 7 neurons encoded target error information, but area 5 neurons did not encode this information. These results suggest that area 5 provides signals for adapting to motor errors and that area 7 provides signals to adapt to target errors.