Vector competence, for Wuchereria bancrofti, of the Anopheles populations in the Bongo district of Ghana
Vector competence, for Wuchereria bancrofti, of the Anopheles populations in the Bongo district of Ghana
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DOI：
10.1179/000349804225003514
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发表时间：
2004-07-01
影响因子：
--
通讯作者：
Gyapong, J
中科院分区：
文献类型：
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作者：
Boakye, DA;Wilson, MD;Gyapong, J
媒介蚊子传播班氏五味子微丝虫病的能力，特别是当蚊子捕食的人的微丝虫病水平非常低时，对于了解淋巴丝虫病的传播动力学非常重要。有关媒介能力和人类宿主微丝虫病负荷之间相关性的数据也与那些试图改进这种疾病传播模型的人有关。大多数相关研究都涉及库拉西丁，而不是按蚊媒介。现已对加纳上东地区一个地区的按蚊种群传播班克罗夫蒂按蚊的能力进行了调查。在自然条件下以20名志愿者为食的野生蚊子是在夜间每小时收集一次，从第一天的21点到第二天的早上6点。总共收集了1348只喂食的雌性蚊子--665只按蚊、662只库蚊和21只伊蚊。大约50%被捕获的蚊子在收集后立即被杀死并被解剖，以便可以统计每个人摄入的班克罗夫蒂白纹伊蚊的数量。其余蚊子在死亡时(如果是在收集后12天内)或在收集后第12天被杀死时进行解剖。除一只库蚊带有一种微丝虫外，所有库蚊和伊蚊均未发现感染班克罗夫氏微丝虫。所有其他被发现感染的蚊子都是一种蚊子。在蚊虫感染期间每小时从志愿者身上采集的血液样本被用来估计这些蚊子所吸食的血液中的微丝虫病时，发现即使在血粉来源的微丝虫病相似的情况下，微丝虫病的摄取和发育中的幼虫数量也有很大的差异。对按蚊汇集数据的回归分析结果表明了限制的过程，尽管需要调查更大的样本来确定这一过程是只发生在按蚊还是在按蚊中，还是在这两个分类群中。
The ability of vector mosquitoes to transmit the microfilariae (mff) of Wuchereria bancrofti, especially when the levels of microfilaraemia in the humans on which the mosquitoes are feeding are very low, is very important for understanding the transmission dynamics of lymphatic filariasis. Data on the correlation between vector competence and the microfilarial load in the human host are also relevant to those trying to improve transmission models for this disease. The majority of the relevant studies have involved culicine rather than anopheline vectors. The competence of populations of Anopheles mosquitoes to transmit W. bancrofti in a district in the Upper East region of Ghana has now been investigated. The wild mosquitoes that fed on 20 volunteers under natural conditions were collected hourly during the night, from 21.00 hours on one day to 06.00 hours on the next. Overall, 1348 fed female mosquitoes - 665 Anopheles, 662 Culex and 21 Aedes - were collected. Approximately 50% of the mosquitoes caught were killed immediately post-collection and dissected so that the number of W. bancrofti mff each had ingested could be counted. The remaining mosquitoes where dissected when they died (if this was within 12 days of collection) or when they were killed on day 12 post-collection. With the exception of one Culex mosquito that harboured one microfilaria, none of the Culex and Aedes mosquitoes were found infected with W. bancrofti. All of the other mosquitoes found infected were An. ga"zbiae s. l. or An. funestus. When fingerprick samples of blood, collected hourly from the volunteers during the mosquito infection, were used to estimate the microfilaraemias in the blood on which these mosquitoes had fed, microfilarial uptake and the number of developing larvae were found to vary considerably even when the microfilaraemias in the bloodmeal source were similar. The results of a regression analysis on the pooled data for the Anopheles mosquitoes indicated the process of limitation, although larger samples need to be investigated to determine whether this process occurs only in An. gambiae s.l. or An. funestus or in both of these taxa.