The age-range of risk of developing multiple sclerosis - Evidence from a migrant population in Australia
The age-range of risk of developing multiple sclerosis - Evidence from a migrant population in Australia
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DOI：
10.1093/brain/123.5.968
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发表时间：
2000-05-01
期刊：
影响因子：
14.5
通讯作者：
McLeod, JG
中科院分区：
文献类型：
--
作者：
Hammond, SR;English, DR;McLeod, JG
多发性硬化症在澳大利亚五个不同地区的澳大利亚出生人口中的患病率与纬度有很强的相关性，随着南纬度的增加，这种疾病变得越来越普遍。在这项研究中，来自英国和爱尔兰（UKI）的不同地区的移民人群的患病率也显示出与纬度的显著相关性，但这种关系受到霍巴特高患病率的强烈影响。除霍巴特外，移民中的流行率远低于其原籍国。在15岁之前从高风险UKI迁移到低风险澳大利亚的人群中，多发性硬化症的患病率与在该年龄或之后迁移的人群没有显著差异，这一发现在一项病例对照研究中得到证实，该研究表明迁移年龄与多发性硬化症风险之间几乎没有关联，这些研究结果表明，多发性硬化症的环境因素的风险可能会在多年的时间内运作，而不仅仅是在童年和成年早期。
The prevalence of multiple sclerosis in the Australian-born population in five different regions of Australia has a strong correlation with latitude, the disease becoming increasingly prevalent with increasing south latitude. In this study, the prevalence in the migrant population from the UK and Ireland (UKI) in the different regions also showed a significant correlation with latitude, but this relationship was strongly influenced by the high prevalence in Hobart. Except for Hobart, the prevalence in migrants was considerably less than that in their countries of origin. The prevalence of multiple sclerosis among those migrating before the age of 15 years from the high-risk UKI to lower-risk Australia was not significantly different to that among those migrating at or after that age, and this finding was confirmed in a case-control study which demonstrated little association between age at migration and risk of developing multiple sclerosis, These findings suggest that the risk from environmental factors in multiple sclerosis may operate over a period of many years and not only in childhood and early adult life.