Functional Role of the Corticoreticular Pathway in Chronic Stroke Patients
Functional Role of the Corticoreticular Pathway in Chronic Stroke Patients
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DOI：
10.1161/strokeaha.111.000269
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发表时间：
2013-04-01
期刊：
影响因子：
8.3
通讯作者：
Yeo, Sang Seok
中科院分区：
文献类型：
--
作者：
Jang, Sung Ho;Chang, Chul Hoon;Yeo, Sang Seok
背景和目的：众所周知，皮质网状通路（CRP）是影响步行能力的重要锥体外系通路。然而，很少有人知道CRP在步行能力恢复中的功能作用。我们调查CRP和步行能力之间的关系在慢性偏瘫stroke patients.Methods-Among 209例连续患者，54例患者，谁表现出完全损伤的皮质脊髓束（CST）在患侧半球的扩散张量纤维束成像，和20名正常人被招募。步行能力测定采用功能性截肢分类。分数各向异性值，表观扩散系数值，纤维体积的CRP和CST被用于扩散张量成像parameters.Results-In受影响的半球，CRP的扩散张量成像参数无显着差异观察患者亚组之间。在健侧半球，与不能行走的患者和正常对照组相比，能够行走的患者的CRP纤维体积显著增加（P
Background and Purpose-The corticoreticular pathway (CRP) is known to be an important extrapyramidal tract for walking ability. However, little is known about the functional role of the CRP in recovery of walking ability. We investigated relation between the CRP and walking ability in chronic hemiparetic stroke patients.Methods-Among 209 consecutive patients, 54 patients, who showed complete injury of the corticospinal tract (CST) in the affected hemisphere on diffusion tensor tractography, and 20 normal subjects were recruited. Functional ambulation category was used in measurement of walking ability. The fractional anisotropy value, apparent diffusion coefficient value, and fiber volume of the CRP and CST were used for the diffusion tensor imaging parameters.Results-In the affected hemisphere, no significant difference in diffusion tensor imaging parameters of the CRP was observed between patient subgroups. In the unaffected hemisphere, patients who were able to walk showed significantly increased fiber volume of the CRP, compared with patients who could not walk and normal control subjects (P