Non-Hodgkin's lymphoma containing both B and T cell clones.
Non-Hodgkin's lymphoma containing both B and T cell clones.
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DOI：
10.1182/blood.v70.1.287.bloodjournal701287
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发表时间：
1987-07
期刊：
影响因子：
20.3
通讯作者：
E. Hu;L. Weiss;R. Warnke;J. Sklar
中科院分区：
文献类型：
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作者：
E. Hu;L. Weiss;R. Warnke;J. Sklar
我们描述了一个病人，其中两个淋巴结活检，间隔18个月披露的组织学和免疫表型证据的非霍奇金淋巴瘤含有肿瘤淋巴细胞的B和T型。免疫球蛋白和T细胞受体基因的分析证实了单独的B和T细胞克隆的存在。此外，免疫基因分型揭示了患者肿瘤内存在第二个B细胞克隆的可能性。本例多克隆淋巴瘤的发生可能与化疗的致癌作用有关，或与以前诊断的自身免疫性疾病引起的淋巴细胞肿瘤转化的易感性有关。另一种可能的解释是，淋巴瘤意味着在这个病人中存在一种转化的淋巴细胞定向干细胞，它能够产生B和T谱系克隆。
We describe a patient in whom two lymph node biopsies removed 18 months apart disclosed histologic and immunophenotypic evidence of a non-Hodgkin's lymphoma containing neoplastic lymphocytes of both B and T type. Analyses of immunoglobulin and T cell receptor genes confirmed the presence of separate B and T cell clones. In addition, immunogenotyping revealed the possibility of a second B cell clone within the patient's tumor. Development of a multiclonal lymphoma in this patient may relate to the carcinogenic effects of chemotherapy or to a predisposition for neoplastic transformation of lymphocytes due to a previously diagnosed autoimmune condition. Another possible explanation is that the lymphoma implies the existence in this patient of a transformed lymphocyte-committed stem cell that is capable of generating both B and T lineage clones.