In situ and invasive squamous cell carcinoma of the vulva in Denmark 1978-2007-a nationwide population-based study
In situ and invasive squamous cell carcinoma of the vulva in Denmark 1978-2007-a nationwide population-based study
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DOI：
10.1016/j.ygyno.2011.03.016
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发表时间：
2011-07-01
影响因子：
4.7
通讯作者：
Kjaer, S. K.
中科院分区：
文献类型：
--
作者：
Baandrup, L.;Varbo, A.;Kjaer, S. K.
目标。目的了解1978年至2007年丹麦外阴原位癌(CIS)和鳞状细胞癌(SC)的发病率。利用丹麦全国癌症登记处，我们确定了1978-2003年间980名被诊断为外阴CIS的妇女(67.8%是SC)和1978-2007年间被诊断为外阴癌的2455名妇女(76.0%是SC)。分析仅限于外阴CIS和起源于SC的癌症。我们评估了特定年龄的发病率、年龄标化发病率和诊断阶段的分布。采用泊松回归分析方法估计年平均百分比变化量。在研究期间，外阴SC CIS的年龄标化发病率每年增加1.97%(95%CI：0.99%至2.96%)，在50岁以下的女性中有急剧增加的趋势。外阴鳞癌的年龄标化发病率呈稳定或略有上升的趋势。然而，在60岁以下的妇女中，观察到了一个显著的上升趋势(每年1.60%；95%可信区间：0.50%到2.71%)。诊断时外阴鳞状细胞癌范围的分布显示出最近几年诊断为局限性疾病的比例较高的趋势。自1978年以来，60岁以下女性的外阴鳞状细胞癌和外阴鳞癌的发病率有所上升。人类乳头瘤病毒(HPV)可以解释这一增长，因此，最近引入的HPV疫苗接种可能在未来导致外阴恶性肿瘤的显著减少。(C)2011年，由爱思唯尔公司出版。
Objective. To determine the incidence of vulvar carcinoma in situ (CIS) and cancer of squamous cell (SC) origin in Denmark in the period 1978-2007.Methods. Using the nationwide Danish Cancer Registry, we identified 980 women diagnosed with vulvar CIS 1978-2003 (67.8% were SC) and 2455 women diagnosed with vulvar cancer 1978-2007 (76.0% were SC). Analysis was restricted to vulvar CIS and cancer of SC origin. We assessed age-specific incidence rates, age-standardized incidence rates, and distribution of stage at diagnosis. Poisson regression analysis was used to estimate the average annual percentage change.Results. During the study period the age-standardized incidence rate of vulvar SC CIS increased by 1.97% per year (95% CI: 0.99% to 2.96%) with a tendency toward a steeper increase among women younger than 50 years. The age-standardized incidence rate of vulvar SC cancer showed a stable or slightly increasing pattern. However, among women below 60 years of age a significantly increasing trend was observed (1.60% per year; 95% CI: 0.50% to 2.71%). The distribution in the extent of vulvar SC cancer at diagnosis showed a tendency toward a higher proportion being diagnosed with localized disease in the more recent calendar years.Conclusions. The incidence rates of vulvar SC CIS and vulvar SC cancer among women below the age of 60 years have increased since 1978. Human papillomavirus (HPV) could explain the increase and thus, the recent introduction of HPV vaccination may in the future result in a notable reduction of vulvar malignancies. (C) 2011 Published by Elsevier Inc.