A Prospective Study of Percutaneous Vertebroplasty for Chronic Painful Osteoporotic Spinal Fractures
A Prospective Study of Percutaneous Vertebroplasty for Chronic Painful Osteoporotic Spinal Fractures
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经皮椎体成形术治疗慢性疼痛性骨质疏松性脊柱骨折的前瞻性研究
DOI：
10.3109/10582452.2012.762819
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发表时间：
2013-03
影响因子：
--
通讯作者：
Tan, Hong-Yu
中科院分区：
文献类型：
--
作者：
Wang, Yi-Sheng;Li, Jia-Zhen;Hao, Ying-Jie;Tan, Hong-Yu
目的评价经皮椎体成形术（PV）治疗慢性疼痛性椎体压缩骨折的疗效。方法：我们进行了一项前瞻性研究，在该研究中，至少3个月的未愈合、疼痛的慢性骨质疏松性椎体骨折[磁共振成像[MRI]上T1低信号和T2高信号]，经MRI证实，被前瞻性地分配接受PV或保守治疗[CT]。主要结果是疼痛缓解在一周，一个月，三个月，六个月，一年，通过视觉模拟量表评分。结果共入组40名参与者，36名[PV组20名中的19名和CT组20名中的17名]完成了1年随访[90%]。基线和1个月之间的平均VAS评分变化为PV后-3.7和CT后-2.4;基线和6个月之间的变化为PV后-3.9和CT后-2.4;基线和1年之间的变化为PV后-4.0和CT后-2.3。两组间平均VAS评分较基线降低的差异为1周时1.3 [P = 0.001]，1个月时1.5 [P = 0.001]，1年时1.6 [P < 0.001]。结论PV比CT更有效地减轻疼痛。它对慢性骨质疏松性椎体骨折和持续性疼痛的亚组患者有效。PV后疼痛立即缓解，并持续一年。
Objectives To evaluate the efficacy of percutaneous vertebroplasty [PV] in patients with chronic painful osteoporotic compression fractures. Methods We performed a prospective study in which participants with unhealed, painful chronic osteoporotic vertebral fractures for at least three months [low signal in T1 and high signal in T2 on magnetic resonance imaging [MRI]], as confirmed by MRI, were prospectively assigned to undergo PV or a conservative treatment [CT]. The primary outcome was pain relief at one week, one month, three months, six months, and one year, as measured by Visual Analog Scale score. Results A total of 40 participants were enrolled and 36 [19 of 20 in the PV group and 17 of 20 in the CT group] completed the one-year follow-up [90 percent]. Changes in mean VAS score between baseline and one month was –3.7 after PV and –2.4 after CT; between baseline and six months was –3.9 after PV and –2.4 after CT; and between baseline and one year was –4.0 after PV and –2.3 after CT. The difference between groups in the reduction of mean VAS score from baseline was 1.3 [P = 0.001] at one week, 1.5 [P = 0.001] at one month, and 1.6 [P < 0.001] at one year. Conclusion PV reduced pain more effectively than did CT. It is effective in a subgroup of patients with chronic osteoporotic vertebral fracture and persistent pain. Pain relief after PV is immediate and is sustained for one year.
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DOI：
10.1016/s0084-3741(10)79489-0
发表时间：
2010
期刊：
Yearbook of Endocrinology
影响因子：
--
作者：
B. Clarke
通讯作者：
B. Clarke
影响因子：
3
作者：
ROLAND, M;MORRIS, R
通讯作者：
MORRIS, R
影响因子：
3.4
作者：
Legroux-Gérot, I;Lormeau, C;Cortet, B
通讯作者：
Cortet, B
影响因子：
158.5
作者：
Buchbinder, Rachelle;Osborne, Richard H.;Murphy, Bridie
通讯作者：
Murphy, Bridie
影响因子：
3
作者：
Rousing, Rikke;Hansen, Karina L.;Lauritsen, Jens M.
通讯作者：
Lauritsen, Jens M.