Progenitor cell mobilization from extramedullary organs.
Progenitor cell mobilization from extramedullary organs.
复制标题
DOI：
10.1007/978-1-61779-943-3_20
复制
发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Kolonin, Mikhail G
中科院分区：
文献类型：
--
作者：
Kolonin, Mikhail G
各种病理状况的病程依赖于干细胞和部分分化的祖细胞的动员。骨髓移植研究表明，髓质造血和内皮祖细胞可以进行动员和运输。虽然骨髓增加其抵抗疾病或修复损伤的资源的能力随着年龄的增长而下降，但其他器官已经成为各种祖细胞群的储存库。本章讨论我们目前对非骨髓来源的祖细胞池的理解，重点是间充质干细胞。提出了髓外祖细胞动员的证据，特别强调白色脂肪组织。
The course of various pathological conditions relies on the mobilization of stem cells and partially differentiated progenitor cells. Bone marrow transplantation studies have demonstrated that medullary hematopoietic and endothelial progenitors can undergo mobilization and trafficking. While the ability of the bone marrow to boost its resources in fighting disease or repairing injury declines with age, other organs have surfaced as reservoirs of various progenitor cell populations. This chapter discusses our current understanding of non-bone marrow-derived progenitor pools, focusing on mesenchymal stem cells. The evidence for the extramedullary progenitor mobilization, with a specific emphasis on white adipose tissue, is presented.