ABNORMALITIES OF DIAPHRAGMATIC MUSCLE IN NEONATES WITH VENTILATED LUNGS
ABNORMALITIES OF DIAPHRAGMATIC MUSCLE IN NEONATES WITH VENTILATED LUNGS
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DOI：
10.1016/s0022-3476(88)80585-7
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发表时间：
1988-12-01
影响因子：
5.1
通讯作者：
SINGER, DB
中科院分区：
文献类型：
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作者：
KNISELY, AS;LEAL, SM;SINGER, DB
几个婴儿和新生儿谁接受了长期的辅助治疗有低于正常的肌肉质量的大体尸检。我们对医院婴儿尸检文件进行了回顾性研究，以确定长期的排便支持是否与选择性影响膈肌的肌纤维横截面积减少有关。我们发现，长期通气辅助可能会使横隔膜肌纤维倾向于废用性萎缩或无法正常生长。这种现象可能会导致婴儿难以脱离母乳喂养。
Several infants and neonates who had received long-termed ventilatory assistance had subnormal diaphragmatic muscle mass on gross necropsy examination. We conducted a retrospective study of our hospital infant necropsy files to determine whether prolonged ventilatory support was associated with diminution in myofiber cross-sectional area selectively affecting the diaphragm. We found that long-term ventilatory assistance may predispose diaphragmatic myofibers to disuse atrophy or to failure of normal growth. This phenomenon may contribute to difficulties in weaning infants from ventilatory support.