INFLUENCE OF DIETARY RESTRICTION ON IMMUNOLOGICAL FUNCTION AND RENAL-DISEASE IN (NZB X NZW) F1 MICE
INFLUENCE OF DIETARY RESTRICTION ON IMMUNOLOGICAL FUNCTION AND RENAL-DISEASE IN (NZB X NZW) F1 MICE
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DOI：
10.1073/pnas.75.3.1500
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发表时间：
1978-01-01
影响因子：
11.1
通讯作者：
GOOD, RA
中科院分区：
文献类型：
--
作者：
FERNANDES, G;FRIEND, P;GOOD, RA
在(NZB。时代)。对于NZW)F1(B/W)小鼠，从断奶时开始适量摄入[10千卡(41.8kJ)/天]与保持较低的体重、较大的T[胸腺来源]细胞有丝分裂原刺激脾细胞的能力以及对同种异体肿瘤细胞的体外和体内刺激产生细胞毒细胞的能力更好地保存有关。当在体外或体内完成致敏时，限制饮食的动物对绵羊红细胞的空斑形成细胞反应也保持得很好。在限制饮食的小鼠中，在对照组中发展起来的自发抑制细胞对斑块形成细胞的抑制活性没有出现。10mo组小鼠血中抗天然DNA循环抗体明显减少。限制饮食摄入量的年龄。组织学分析显示肾脏疾病的发展和γ-射线的沉积。限制饮食的小鼠肾小球毛细血管球蛋白明显受到抑制。因此，从断奶时开始限制饮食似乎可以显著延长易患自身免疫疾病(NZB)患者的寿命。NZW)F1雄性和雌性小鼠，并改变淋巴细胞免疫功能，从而减少与进行性肾脏疾病相关的自身免疫过程和免疫攻击。
In (NZB .times. NZW)F1 (B/W) mice, moderate caloric intake [10 kcal (41.8 kJ)/day] from the time of weaning was associated with maintenance of lower body weight, greater capacity of spleen cells to be stimulated with T[thymus-derived]-cell mitogens, and better preserved capacity to generate cytotoxic cells in response to in vitro and in vivo stimulation with allogeneic tumor cells. Plaque-forming cell response to sheep erythrocytes was also well maintained in animals on the restricted diets when sensitization was accomplished in vitro or in vivo. Spontaneous suppressor cell activity against plaque-forming cells that developed in controls did not appear in the mice on the restricted diet. Significantly less circulating antibody to native DNA was present in the blood of mice 10 mo. of age when their dietary intake was restricted. Histological analysis revealed that the development of renal disease and the deposition of .gamma. globulin in the glomerular capillaries was markedly inhibited in the mice on restricted diets. Dietary restriction from the time of weaning thus appears to prolong significantly the life of autoimmune-prone (NZB .times. NZW)F1 male and female mice and to alter lymphoid cell immune function, thereby decreasing the autoimmune processes and immunological assault associated with progressive renal disease in these animals.