Structural sexual dimorphisms in the anteroventral periventricular nucleus of the rat hypothalamus are sensitive to gonadal steroids perinatally, but develop peripubertally
Structural sexual dimorphisms in the anteroventral periventricular nucleus of the rat hypothalamus are sensitive to gonadal steroids perinatally, but develop peripubertally
复制标题
DOI：
10.1159/000126950
复制
发表时间：
1996-02-01
影响因子：
4.1
通讯作者：
Gorski, RA
中科院分区：
文献类型：
--
作者：
Davis, EC;Shryne, JE;Gorski, RA
雌性大鼠下丘脑前腹侧室周核（AVPV）的体积比雄性大。该实验室的一项初步研究发现，这种两性异形在第30天至第91天之间发展。本研究旨在证实和扩展这些发现，并确定内源性性腺类固醇激素的作用，在发展中的AVPv出生后。结果表明，性二态性AVPV体积出现在30和40天之间，核的长度变得性二态性60和80天之间。此外，雌性动物的AVPv体积和长度在第30天和第80天之间均增加。雄性大鼠在出生当天去势，成年后AVPv体积发生性别逆转，出生后5天雄性大鼠去势，AVPv长度发生性别逆转;在这些年龄段切除雌性大鼠卵巢对两个参数均无影响。此外，在男性和女性，AVPv体积和长度不受性腺切除术在以后的年龄。AVPV似乎是由睾丸激素的影响，但结构上的变化，在青春期左右的女性，显然挑战目前的性别分化的概念，限制了出生后早期的过程。
The volume of the anteroventral periventricular nucleus (AVPV) of the rat hypothalamus is larger in females than in males. A preliminary study from this laboratory found that this sexual dimorphism develops between days 30 and 91. The present study was designed to confirm and extend these findings and to determine the role of endogenous gonadal steroids in the development of the AVPv postnatally. The results indicate that the sexual dimorphism in AVPv volume arises between days 30 and 40 and that the length of the nucleus becomes sexually dimorphic between days 60 and 80. Additionally, both AVPv volume and length increased between days 30 and 80 in females. Castration of male rats on the day of birth sex-reversed AVPv volume in adulthood and AVPv length was sex-reversed by castration of males 5 days after birth; ovariectomy of females at these ages had no effect on either parameter. Moreover, in both males and females, AVPv volume and length were unaffected by gonadectomy at later ages. That the AVPV appears to be influenced by testicular hormones neonatally, but changes structurally around the time of puberty in females, clearly challenges current concepts of sexual differentiation that limit the process to the early postnatal period.