Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers
Prevalence of insulin resistance syndrome in southwestern France and its relationship with inflammatory and hemostatic markers
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DOI：
10.2337/diacare.25.8.1371
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发表时间：
2002-08-01
期刊：
影响因子：
16.2
通讯作者：
Ferrières, J
中科院分区：
文献类型：
--
作者：
Marques-Vidal, P;Mazoyer, E;Ferrières, J
目的 - 评估法国西南部 35-64 岁人群的代表性样本中胰岛素抵抗综合征 (IRS) 的患病率以及与炎症和止血标志物的关系。 研究设计和方法 - 在这项横断面研究中，收集了 597 名男性和 556 名女性的数据，并评估了 BMI、血压、总胆固醇和高密度脂蛋白胆固醇水平、甘油三酯水平、血糖水平、血浆胰岛素水平、白细胞计数、纤维蛋白原水平、VII因子水平、血管性血友病因子、C反应蛋白水平、可溶性细胞间粘附分子、可溶性血管细胞粘附分子-1和可溶性CD14。胰岛素抵抗的定义是稳态模型评估大于或等于 3.8。 结果 - IRS 患病率男性高于女性（分别为 23% 和 12%；P < 0.001），并且男女均随着年龄的增长而增加（35-44 岁、45-54 岁和 55-64 岁年龄组的 IRS 患病率分别为 9%、24% 和 34%，男性和 4 岁年龄段的 IRS 患病率分别为 9%、24% 和 34%）。 10%，女性为 21%）。在调整年龄、饮酒、吸烟以及女性更年期后，IRS 受试者（男性和女性）的白细胞计数、VII 因子水平、凝血因子 VII 水平和 C 反应蛋白水平显着高于其他受试者。在男性中，可溶性细胞间粘附分子和可溶性血管细胞粘附分子-1 进一步增加，而在女性中，差异接近显着。相反，两性的纤维蛋白原、血管性血友病因子和可溶性 CD14 没有发现差异。结论 - IRS 在法国西南部居民中相对常见，并且与止血和炎症参数的有害增加有关。
OBJECTIVE - To assess the prevalence and relationships of insulin resistance syndrome (IRS) with inflammatory and hemostatic markers in a representative sample of the population of Southwestern France aged 35-64 years.RESEARCH DESIGN AND METHODS - In this cross-sectional study, data were collected from 597 men and 556 women and were assessed regarding BMI, blood pressure, total and HDL cholesterol levels, triglyceride level, glucose level, plasma insulin level, white blood cell count, fibrinogen level, factor VII level, von Willebrand factor, C-reactive protein level, soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule-1, and soluble CD14. Insulin resistance was defined by homeostasis model assessment greater than or equal to3.8.RESULTS - Prevalence of IRS was higher in men than in women (23 vs. 12%, respectively; P < 0.001) and increased with age in both sexes (9, 24, and 34% for age groups 35-44, 45-54, and 55-64 years, respectively, for men and 4, 10, and 21% for women). After adjusting for age, alcohol consumption, tobacco smoking, and also for menopause in women, subjects (men and women) with IRS had significantly higher white blood cell count, factor VII levels, coagulating factor VII levels, and C-reactive protein levels than the other subjects. In men, further increases in soluble intercellular adhesion molecule and soluble vascular cell adhesion molecule-1 were noted, whereas in women, the differences were borderline significant. Conversely, no differences were found in fibrinogen, von Willebrand factor, and soluble CD14 in both sexes.CONCLUSIONS - IRS is relatively common in residents of Southwestern France and is related to a deleterious increase in hemostatic and inflammatory parameters.