Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics
Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics
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DOI：
10.1080/10715760600617843
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发表时间：
2006-05-01
影响因子：
3.3
通讯作者：
Chopra, RK
中科院分区：
文献类型：
--
作者：
Bhagavan, HN;Chopra, RK
本文综述了辅酶Q10(CoQ10)的吸收、代谢和药代动力学方面的研究进展。辅酶Q10在细胞生物能量学中具有重要作用。辅酶Q10也是一种重要的抗氧化剂。由于辅酶Q10的疏水性和大分子量，其吸收缓慢且有限。在膳食补充剂的情况下，溶解的辅酶Q10配方显示出更高的生物利用度。其Tmax约为6h，消除半衰期约为33h，健康成人血浆辅酶Q_(10)的参考区间为0.40~1.91mU/L。补充辅酶Q10到一定程度后，血浆辅酶Q10的升高与摄入剂量之间存在合理的相关性。动物数据显示，大剂量的辅酶Q10被包括心脏和大脑线粒体在内的所有组织摄取。这对人类疾病的治疗应用具有意义，而且有证据表明，它对心血管和神经退行性疾病有好处。CoQ10有很好的安全记录。
Available data on the absorption, metabolism and pharmacokinetics of coenzyme Q10 (CoQ10) are reviewed in this paper. CoQ10 has a fundamental role in cellular bioenergetics. CoQ10 is also an important antioxidant. Because of its hydrophobicity and large molecular weight, absorption of dietary CoQ10 is slow and limited. In the case of dietary supplements, solubilized CoQ10 formulations show enhanced bioavailability. The T max is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma CoQ10 range from 0.40 to 1.91 mu mol/l in healthy adults. With CoQ10 supplements there is reasonable correlation between increase in plasma CoQ10 and ingested dose up to a certain point. Animal data show that CoQ10 in large doses is taken up by all tissues including heart and brain mitochondria. This has implications for therapeutic applications in human diseases, and there is evidence for its beneficial effect in cardiovascular and neurodegenerative diseases. CoQ10 has an excellent safety record.