Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils
Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils
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DOI：
10.1080/09629350310001633342
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发表时间：
2003-12-01
影响因子：
4.6
通讯作者：
Yamaguchi, H
中科院分区：
文献类型：
--
作者：
Abe, S;Maruyama, N;Yamaguchi, H
背景：在芳香疗法中，精油被用作抗炎药物，但其作用机制的实验研究非常有限。方法：采用肿瘤坏死因子-α诱导的人外周血中性粒细胞黏附反应测定中性粒细胞的激活。结果：不同浓度的精油均能抑制肿瘤坏死因子-α诱导的中性粒细胞黏附，其中香茅、天竺葵油和留兰香油在0.0125%的浓度下仍能明显抑制中性粒细胞的黏附。其主要成分柠檬醛、香叶醇、香茅醇和香芹酮对中性粒细胞黏附的抑制作用相似。而非常流行的精油茶树油和薰衣草油在浓度范围内对中性粒细胞活性无明显抑制作用。结论：某些精油在体外可抑制低浓度(0.0125-0.025%)的肿瘤坏死因子-α对中性粒细胞的激活作用。
Background: In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited. Aims: To assess their anti-inflammatory activities, effects of essential oils on neutrophil activation were examined in vitro.Methods: Neutrophil activation was measured by tumor necrosis factor-alpha (TNF-alpha)-induced adherence reaction of human peripheral neutrophils.Results: All essential oils tested at 0.1% concentration suppressed TNF-alpha-induced neutrophil adherence, and, in particular, lemongrass, geranium and spearmint oils clearly lowered the reaction even at 0.0125%. Similar inhibitory activities for the neutrophil adherence were obtained by their major constituent terpenoids: citral, geraniol, citronellol and carvone. In contrast, very popular essential oils, tea tree oil and lavender oil, did not display the inhibitory activity at the concentration.Conclusion: Thus, some essential oils used as anti-inflammatory remedies suppress neutrophil activation by TNF-alpha at a low concentration (0.0125-0.025%) in vitro.