Photochemical activation of acylated .alpha.-thrombin
Photochemical activation of acylated .alpha.-thrombin
复制标题
酰化α-凝血酶的光化学活化
DOI：
10.1021/ja00238a062
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发表时间：
1987
影响因子：
15
通讯作者：
N. Porter
中科院分区：
文献类型：
--
作者：
A. D. Turner;S. Pizzo;G. Rozakis;N. Porter
综上所述，首次实现了（+）-叶下珠苷的全合成。该策略的中心特征是Koenigs-Knorr方案，随后进行苄基-乙酰基交换以构建二糖2，然后Mitsonobu偶联至3。虽然Mitsonobu反应中缺乏高立体选择性有点令人失望，但它几乎没有减损合成的整体效率，因为所有其他反应都以良好至优异的产率进行。本研究由美国国立卫生研究院（普通医学科学研究所）通过GM 29028号赠款提供支持。
In summary, the first total synthesis of (+)-phyllanthoside has been achieved. The central features of the strategy were the Koenigs-Knorr protocol followedby benzyl-acetyl interchange to construct disaccharide 2 and then a Mitsonobu coupling to 3. While the lack of high stereoselectivity in the Mitsonobu reaction is somewhat disappointing, it detracts little from the overall efficiency of the synthesis inthat all other reactions proceed in good to excellent yield.Acknowledgment. Support for this investigation was provided by the National Institutes of Health (Institute of General Medical Sciences) through Grant GM 29028.