Role of locus coeruleus alpha1-adrenoceptors in motor activity in rats.
Role of locus coeruleus alpha1-adrenoceptors in motor activity in rats.
复制标题
蓝斑α1-肾上腺素受体在大鼠运动活动中的作用。
DOI：
10.1002/syn.20074
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Quartermain,David
中科院分区：
文献类型：
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作者：
Stone,EricA;Lin,Yan;Ahsan,Rashedul;Quartermain,David
蓝斑（LC）是否参与控制运动活动的问题一直存在争议，因为难以证明该核或背侧去甲肾上腺素能束（DNB）神经毒性损伤后的永久性运动缺陷。在本实验中，在大鼠中，急性局部阻断（特拉唑嗪）或刺激（苯肾上腺素）LC α1-肾上腺素受体分别阻断或刺激新笼和家笼中的探索行为。此外，先前通过i. p. DSP 4对DNB的损伤消除了局部LC α1-受体操纵的行为变化，但本身并不影响新笼或饲养笼中的运动活动。这些发现与以下假设一致：完整的LC确实有助于运动活动控制，部分由其α1-受体发挥作用;然而，该核的永久性损失由剩余的CNS运动结构补偿。Synapse 54：164-172，2004年。© 2004 Wiley利斯公司
The question of whether or not the locus coeruleus (LC) participates in the control of motor activity has been controversial due to difficulties in demonstrating permanent motor deficits after neurotoxic lesions of this nucleus or of the dorsal noradrenergic bundle (DNB). In the present experiments it was shown in rats that acute local blockade (with terazosin) or stimulation (with phenylephrine) of LC α1‐adrenoceptors respectively blocked or stimulated exploratory behavior in a novel cage and the home cage. Moreover, previous lesion of the DNB by i.p. DSP4 abolished the behavioral changes to local LC α1‐receptor manipulation but did not affect motor activity in the novel or home cage by itself. These findings are consistent with the hypothesis that the intact LC does contribute to motor activity control, exerted in part by its α1‐receptors; however, the permanent loss of this nucleus is compensated for by remaining CNS motor structures. Synapse 54:164–172, 2004. © 2004 Wiley‐Liss, Inc.