Control of movement distance in Parkinson's disease
Control of movement distance in Parkinson's disease
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DOI：
10.1002/mds.1220
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发表时间：
2001-11-01
影响因子：
8.6
通讯作者：
Corcos, DM
中科院分区：
文献类型：
--
作者：
Pfann, KD;Buchman, AS;Corcos, DM
帕金森病（PD）运动过程中的肌电图（EMG）模式的研究往往产生矛盾的结果，使得无法推导出一套规则来解释肌肉如何被激活以执行不同的运动任务。我们试图阐明PD患者在快速运动过程中与运动距离控制相关的EMG参数调制的变化。具体而言，我们研究了14例PD症状相对较轻的患者和14例年龄、性别、身高和体重相似的对照受试者在广泛距离（5-72度）的快速肘关节屈曲运动期间的表面EMG活动。PD组在EMG调制中表现出几种变化，包括激动剂爆发持续时间的调制受损：激动剂爆发数量增加;受损更严重受试者中激动剂EMG幅度的缩放减少;以及受损最严重受试者中拮抗剂和激动剂信号的时间重叠增加。这些研究结果表明，PD中进行性运动功能障碍伴随着调节肌肉激活的赤字增加。这些结果有助于澄清以前不同的，有时是相互矛盾的结果，肌电图模式与PD的主题。(C)2001运动障碍协会。
Studies of electromyographic (EMG) patterns during movements in Parkinson's disease (PD) have often yielded contradictory results, making it impossible to derive a set of rules to explain how muscles are activated to perform different movement tasks. We sought to clarify the changes in modulation of EMG parameters associated with control of movement distance during fast movements in patients with PD. Specifically, we studied surface EMG activity during rapid elbow, flexion movements over a wide range of distances (5-72 degrees) in 14 patients with relatively mild symptoms of PD and 14 control subjects of similar age, sex, height, and weight. The PD group exhibited several changes in EMG modulation including impaired modulation of agonist burst duration: increased number of agonist bursts; reduced scaling of agonist EMG magnitude in the more severely impaired subjects: and increased temporal overlap of the antagonist and agonist signals in the most severely impaired subjects. These findings suggest that progressive motor dysfunction in PD is accompanied by increasing deficits in modulating muscle activation. These results help clarify previous disparate and sometimes contradictory results of EMG patterns in subjects with PD. (C) 2001 Movement Disorder Society.