Clinical Significance of the G8 Screening Tool in Elderly Patients With Oral Squamous Cell Carcinoma
Clinical Significance of the G8 Screening Tool in Elderly Patients With Oral Squamous Cell Carcinoma
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G8 筛查工具对老年口腔鳞状细胞癌患者的临床意义
DOI：
10.1007/s00784-019-03056-y
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Kurita H.
中科院分区：
文献类型：
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作者：
Yamada SI;Hasegawa T;Okuyama K;Yamakawa N;Okura M;Hashidume M;Yanamoto S;Akashi M;Kirita T;Umeda M;Kurita H.
目的本研究通过多中心分析探讨了 G8 筛查工具在老年口腔鳞状细胞癌 (OSCC) 患者中的临床意义。材料和方法对 438 名 75 岁及以上原发性 OSCC 患者的病历进行回顾性分析。为了检验G8筛查工具对老年OSCC患者的临床意义，对老年OSCC患者的自力更生（SR）率和预后因素进行统计分析。结果G8筛查工具的平均得分为10.9±2.93。在接受者操作特征曲线分析中，G8 评分的 SR 截止值为 9.5。 G8 评分 < 9.5 的患者的五年总生存率为 40.1%，G8 评分≥ 9.5 的患者的五年总生存率为 58.4%（p< 0.01）。 G8 评分 < 9.5 的患者的五年癌症特异性率为 34.3%，G8 评分≥ 9.5 的患者为 55.7%（p< 0.01）。 G8 评分 < 9.5 的患者的五年 SR 率为 40.7%，G8 评分≥ 9.5 的患者的五年 SR 率为 55.3% (p< 0.05)。多变量分析确定了高龄（≥ 80 vs < 80；HR，1.437；95%CI，1.181–1.843；p< 0.01），较差的ECOG-PS（2–4 vs 0–1；HR，1.560；95%CI，1.14–2.106；p< 0.01），和标准治疗（非标准治疗与标准治疗；HR， 0.598； 95%CI, 0.405–0.910;p< 0.05) 作为 SR 的重要独立预后因素。较低的 G8 评分与较差的 SR 相关（≥ 9.5 vs < 9.5；HR，0.765；95%CI，0.575–1.034；p= 0.081）。结论 G8 评分对老年 OSCC 患者的临床意义已得到证实，其与 ECOG-PS 的结合可能有助于评估其预后。
ObjectivesThe present study investigated the clinical significance of the G8 screening tool in elderly oral squamous cell carcinoma (OSCC) patients using a multicenter analysis.Materials and methodsThe medical records of 438 primary OSCC patients aged 75 years and older were retrospectively reviewed. To examine the clinical significance of the G8 screening tool in elderly OSCC patients, self-reliance (SR) rates and prognostic factors were statistically analyzed.ResultsThe mean score of the G8 screening tool was 10.9 ± 2.93. The SR cut-off value of the G8 score was 9.5 in a receiver operating characteristic curve analysis. Five-year overall survival rates were 40.1% in patients with a G8 score < 9.5 and 58.4% in those with a G8 score ≥ 9.5 (p< 0.01). Five-year cancer-specific rates were 34.3% in patients with a G8 score < 9.5 and 55.7% in those with a G8 score ≥ 9.5 (p< 0.01). Five-year SR rates were 40.7% in patients with a G8 score < 9.5 and 55.3% in those with a G8 score ≥ 9.5 (p< 0.05). A multivariate analysis identified an advanced age (≥ 80 vs < 80; HR, 1.437; 95%CI, 1.181–1.843;p< 0.01), poorer ECOG-PS (2–4 vs 0–1; HR, 1.560; 95%CI, 1.14–2.106;p< 0.01), and standard treatment (non-standard therapy vs standard therapy; HR, 0.598; 95%CI, 0.405–0.910;p< 0.05) as significant independent prognostic factors for SR. A lower G8 score was associated with poorer SR (≥ 9.5 vs < 9.5; HR, 0.765; 95%CI, 0.575–1.034;p= 0.081).ConclusionThe clinical significance of the G8 score for elderly OSCC patients was demonstrated and its combination with ECOG-PS may be useful for assessing their prognoses.