Evaluation of Acquired Color Vision Deficiency in Glaucoma Using the Rabin Cone Contrast Test
Evaluation of Acquired Color Vision Deficiency in Glaucoma Using the Rabin Cone Contrast Test
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DOI：
10.1167/iovs.14-14079
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发表时间：
2014-10-01
影响因子：
4.4
通讯作者：
Ohji, Masahito
中科院分区：
文献类型：
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作者：
Niwa, Yuichi;Muraki, Sanae;Ohji, Masahito
目的。采用拉宾锥对比试验（RCCT）评价青光眼获得性色觉缺陷。选取青光眼患者27只眼（青光眼组）和正常人27只眼（对照组）作为研究对象。在两组中使用RCCT测量长(L)、中(M)和短(S) CCT评分（分别为L CCT、M CCT和S CCT）。采用瑞典交互式阈值算法30-2进行Humphrey自动视野检查，并评估平均偏差（MD）。采用高分辨率光学相干断层成像技术测量青光眼组黄斑神经节细胞/内丛状层（GCIPL）厚度。青光眼组的平均M CCTs和S CCTs均显著低于对照组（M CCTs, 80.7 +/- 16.8 vs. 91.9 +/- 8.22; S CCTs, 83.9 +/- 19.5 vs. 97.4 +/- 3.77）；L cct与对照组无显著差异（P = 0.065）（分别为91.8 +/- 12.8和97.4 +/- 3.50）。M CCTs和S CCTs与MD （M CCTs, r = 0.47; S CCTs, r = 0.44；两组比较均P < 0.05）和GCIPL厚度（M CCTs, r = 0.70; P < 0.0001; S CCTs, r = 0.57; P < 0.01）显著相关。青光眼组RCCT测得的色差分辨阈值与对照组有显著差异，且与MD和GCIPL厚度相关。RCCT可用于评估青光眼的获得性色觉缺陷，并有助于提高目前对青光眼损伤病理生理的理解。
PURPOSE. To evaluate acquired color vision deficiency in glaucoma by using the Rabin cone contrast test (RCCT).METHODS. Twenty-seven eyes of 27 patients with glaucoma (glaucoma group) and 27 eyes of 27 normal subjects (control group) were included in this study. Long (L), medium (M), and short (S) CCT scores (L CCTs, M CCTs, and S CCTs, respectively) were measured using the RCCT in both groups. Visual field examinations were performed with Humphrey automated perimetry using the Swedish interactive thresholding algorithm 30-2, and the mean deviation (MD) was evaluated. The macular ganglion cell/inner plexiform layer (GCIPL) thickness was measured using high-definition optical coherence tomography in the glaucoma group.RESULTS. The mean M CCTs and S CCTs in the glaucoma group were significantly lower (P < 0.05 for both comparisons) than in the control group (M CCTs, 80.7 +/- 16.8 vs. 91.9 +/- 8.22; S CCTs, 83.9 +/- 19.5 vs. 97.4 +/- 3.77, respectively); the L CCTs did not differ significantly (P = 0.065) from those of the controls (91.8 +/- 12.8 vs. 97.4 +/- 3.50, respectively). The M CCTs and S CCTs were correlated significantly with those of MD (M CCTs, r = 0.47; S CCTs, r = 0.44; P < 0.05 for both comparisons) and GCIPL thickness (M CCTs, r = 0.70; P < 0.0001; S CCTs, r = 0.57; P < 0.01).CONCLUSIONS. The chromatic discrimination thresholds measured by RCCT in the glaucoma group were significantly different from those measured in the control group and were correlated with the MD and GCIPL thickness. The RCCT may be useful for evaluating acquired color vision deficiency in glaucoma and may help advance current understanding of the pathophysiology of glaucomatous damage.