Skull Factors Affecting Outcomes of Magnetic Resonance-Guided Focused Ultrasound for Patients with Essential Tremor
Skull Factors Affecting Outcomes of Magnetic Resonance-Guided Focused Ultrasound for Patients with Essential Tremor
复制标题
DOI：
10.3349/ymj.2019.60.8.768
复制
发表时间：
2019-08-01
影响因子：
2.4
通讯作者：
Chang, Jin Woo
中科院分区：
文献类型：
--
作者：
Chang, Kyung Won;Park, Yong-Sook;Chang, Jin Woo
目的：磁共振引导聚焦超声（MRgFUS）丘脑切开术已成为医学难治性特发性震颤（ET）的标准治疗方法。ET患者的颅骨密度比（SDR）和颅骨体积目前被认为是MRgFUS成功应用的有用指标。我们比较了SDR高于0.4和0.45的MRgFUS丘脑切开术的临床结局。我们还描述了模式SDR和颅骨体积在韩国ET患者谁有资格被筛选MRgFUS.Materials和方法：在筛选318 ET患者，我们评估模式的颅骨密度和颅骨体积根据年龄和性别。50例ET患者接受了MRgFUS治疗。我们研究了SDR和颅骨体积对ET治疗参数和结局的影响。结果：318例ET患者的平均SDR为0.45 ± 0.11，颅骨体积为315.74 ± 40.95 cm（3）。男性患者的SDR高于女性患者（p=0.047）。随着年龄的增长，颅骨体积显著减小。SDR与颅骨体积呈线性负相关。在治疗参数中，最高温度与SDR呈正相关，而超声次数与SDR或颅骨体积无关。震颤的结果也不相关的SDR或skull volume.Conclusion：SDR变化范围很大，从0.11到0.73，和男性有较高的SDR。治疗参数和临床结果不受SDR或颅骨体积的影响。
Purpose: Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy has become a standard treatment for medically intractable essential tremor (ET). Skull density ratio (SDR) and skull volume in patients with ET are currently considered useful indicators of the successful application of MRgFUS. We compared the clinical outcomes of MRgFUS thalamotomy with SDR above 0.4 and 0.45. We also described patterns of SDR and skull volume in Korean patients with ET who were eligible to be screened for MRgFUS.Materials and Methods: In screening 318 ET patients, we evaluated patterns of skull density and skull volume according to age and sex. Fifty patients with ET were treated with MRgFUS. We investigated the effects of SDR and skull volume on treatment parameters and the outcomes of ET.Results: The mean SDR of the 318 ET patients was 0.45 +/- 0.11, and that for skull volume was 315.74 +/- 40.95 cm(3). The male patients had a higher SDR than female patients (p=0.047). Skull volume significantly decreased with aging. SDR and skull volume exhibited a linear negative relationship. Among therapeutic parameters, maximal temperature was positively related to SDR, while sonication number was not related to either SDR or skull volume. Tremor outcome was also not related to SDR or skull volume.Conclusion: SDR varied widely from 0.11 to 0.73, and men had a higher SDR. Therapeutic parameters and clinical outcomes were not affected by SDR or skull volume.