Repeated quinpirole treatments produce neurochemical sensitization and associated behavioral changes in female hamsters.
Repeated quinpirole treatments produce neurochemical sensitization and associated behavioral changes in female hamsters.
复制标题
重复的喹吡罗治疗会导致雌性仓鼠产生神经化学敏化和相关的行为变化。
DOI：
10.1007/s00213-006-0468-2
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发表时间：
2006
影响因子：
3.4
通讯作者：
Meisel,RobertL
中科院分区：
文献类型：
--
作者：
Chester,JuliaA;Mullins,AmandaJ;Nguyen,ChauH;Watts,ValJ;Meisel,RobertL
ObjectivesThe present study was designed to examine repeated treatment with the D2-like dopamine receptor agonists，quinpirole，会对D1多巴胺受体产生神经化学敏化作用以类似于先前用于敏化异源多巴胺信号传导的方式在雌性仓鼠中介导过程和相关行为变化材料和方法雌性仓鼠每周接受两次喹吡罗（1.5mg/kg）或盐水注射，持续7周，在此期间监测装袋行为和体重。在接下来的2周内，测试仓鼠的声惊吓反应（PPI）和性行为的前脉冲抑制的差异。腺苷酸环化酶激活试验，然后进行解剖组织从核的脑桥和尾壳核。结果重复治疗quinpirole增加pouching行为和体重和破坏PPI。在重复quinpirole的性活动中没有发现变化。先前quinpirole治疗增强了尾壳核中D1多巴胺受体刺激的腺苷酸环化酶活性，该活性通过与D1多巴胺拮抗剂共孵育而被阻断，SCH 23390。结论D2-在体内的类似受体可以产生摄食行为和感觉处理的变化，这是与D1多巴胺受体介导的信号在尾壳核的敏化。
RationaleRepeated stimulation of dopaminergic pathways with dopamine receptor agonists can produce both neurochemical and behavioral sensitization.ObjectivesThe present study was designed to examine whether repeated treatment with the D2-like dopamine receptor agonist, quinpirole, would produce neurochemical sensitization of D1dopamine receptor-mediated processes and associated behavioral changes in female hamsters in a manner analogous to that previously used to sensitize heterologous dopamine signaling pathways in derived cell lines.Materials and methodsFemale hamsters received two injections of quinpirole (1.5 mg/kg) or saline each week for 7 weeks, during which time pouching behavior and body weight were monitored. Over the next 2 weeks, hamsters were tested for differences in prepulse inhibition of the acoustic startle response (PPI) and sexual behavior. Adenylate cyclase activation assays were then performed on dissected tissue from the nucleus accumbens and caudate–putamen.ResultsRepeated treatment with quinpirole increased pouching behavior and body weight and disrupted PPI. No changes in sexual activity in response to repeated quinpirole were found. Prior quinpirole treatment enhanced D1dopamine receptor-stimulated adenylate cyclase activity in the caudate–putamen that was blocked by co-incubation with the D1dopamine antagonist, SCH23390.ConclusionsThese results show that repeated activation of D2-like receptors in vivo can produce changes in feeding behavior and sensory processing that is associated with sensitization of D1dopamine receptor-mediated signaling in the caudate–putamen.