Oral Arginine Metabolism May Decrease the Risk for Dental Caries in Children
Oral Arginine Metabolism May Decrease the Risk for Dental Caries in Children
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DOI：
10.1177/0022034513487907
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发表时间：
2013-07-01
影响因子：
7.6
通讯作者：
Burne, R. A.
中科院分区：
文献类型：
--
作者：
Nascimento, M. M.;Liu, Y.;Burne, R. A.
口腔细菌通过精氨酸脱亚胺酶系统（ADS）代谢精氨酸，提高了局部pH值，可以中和糖代谢的酸化作用，降低口腔生物膜的致癌性。为了探讨口腔精氨酸代谢与儿童龋病的关系，我们测量了100名儿童口腔样本中的ADS活性，并将其与龋病状况和牙列类型进行了相关性分析。龈上牙菌斑采集于无龋损（PF）、牙本质（PD）和牙釉质（PE）龋损的牙表面。无论儿童的龋齿状况或牙列类型如何，PF（378.6）的ADS活性明显高于PD （208.4, p < 0.001）和PE （194.8, p = 0.005）。不同龋病状态儿童唾液溶精活性差异无统计学意义。混合模型分析显示，尽管儿童年龄、龋齿状况和牙列不同，但牙菌斑龋齿状况与ADS活性显著相关（p < 0.001），健康牙菌斑与病变牙菌斑相比，预示着更高的ADS活性。牙菌斑精氨酸代谢在儿童和牙齿部位之间差异很大，这可能影响他们对龋齿的易感性。
Arginine metabolism by oral bacteria via the arginine deiminase system (ADS) increases the local pH, which can neutralize the effects of acidification from sugar metabolism and reduce the cariogenicity of oral biofilms. To explore the relationship between oral arginine metabolism and dental caries experience in children, we measured ADS activity in oral samples from 100 children and correlated it with their caries status and type of dentition. Supragingival dental plaque was collected from tooth surfaces that were caries-lesion-free (PF) and from dentinal (PD) and enamel (PE) caries lesions. Regardless of children's caries status or type of dentition, PF (378.6) had significantly higher ADS activity compared with PD (208.4; p < .001) and PE (194.8; p = .005). There was no significant difference in the salivary arginolytic activity among children with different caries status. Mixed-model analysis showed that plaque caries status is significantly associated with ADS activity despite children's age, caries status, and dentition (p < .001), with healthy plaque predicting higher ADS activity compared with diseased plaque. Plaque arginine metabolism varies greatly among children and tooth sites, which may affect their susceptibility to caries.