BIOLOGICAL-ACTIVITY AND HISTOCOMPATIBILITY OF DENSE AL2 O3- MGO CERAMIC IMPLANTS IN RATS
BIOLOGICAL-ACTIVITY AND HISTOCOMPATIBILITY OF DENSE AL2 O3- MGO CERAMIC IMPLANTS IN RATS
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DOI：
10.1002/jbm.820070328
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发表时间：
1973-01-01
期刊：
影响因子：
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通讯作者：
HEIMKE, G
中科院分区：
文献类型：
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作者：
GRISS, P;ANDRIANW.HV;HEIMKE, G
三类致密氧化铝陶瓷（Al2O3）99.7%，MgO 0.3%；将密度超过 3.9 g/cm3 且仅平均颗粒尺寸 (5-15μ) 不同的不锈钢 (V4A) 板植入 6 个月大的雄性 Wistar 大鼠的左股骨中。使用光和扫描电子显微镜技术来研究组织反应和陶瓷表面。陶瓷板和不锈钢板都被软组织层包围，根据植入物类型的不同，软组织层在纤维/细胞比率方面差异很大。虽然身体倾向于用主要由纤维和一些不活跃的纤维细胞组成的或多或少的小无血管组织包围金属板，但在陶瓷植入物周围，出现了具有成骨细胞和软骨细胞化生迹象的高度细胞化的间充质软组织。与该间质相邻，出现了新形成的编织骨的密集袖带，显示出许多活跃的骨细胞。在实验结束时（术后70周），新形成的间质的化生倾向和周围骨中的骨细胞活性均没有明显下降，而金属植入物周围的组织在术后12-24周达到稳定的相对反应状态。没有异物反应的陶瓷表面间充质紧密接触支持了这样的观点：氧化铝陶瓷倾向于融入人体的生理环境，而金属则被生物活性低的纤维组织层“排除”。未检测到陶瓷表面的腐蚀。
Three types of dense alumina oxide ceramic (Al2O3) 99.7%, MgO 0.3%; density more than 3.9 g/cm3differing only in their average grain size (5–15μ) and stainless steel (V4A) plates were implanted into the left femur of male Wistar rats 6 months old. Light and scanning electron microscopic techniques were used to investigate tissue reaction and the ceramic surface. Both ceramic and stainless steel plates were surrounded by a soft tissue layer that differed greatly depending on the implant type in respect to the fiber/cell ratio. While the body tended to enclose the metal plate with a small more or less avascular tissue mostly composed of fibers and some inactive fibrocytes, around the ceramic implants a highly cellulated soft tissue of mesenchyme character developed with signs of osteoblast and chondrocyte metaplasia. Adjacent to this mesenchyme a dense cuff of newly formed woven bone arose, showing numerous active osteocytes. Both metaplastic tendency of the newly formed messenchyme and osteocyte activity in the surrounding bone did not decrease remarkably towards the end of the experiment (70 weeks after operation), while the tissue around metal implants reached a steady relatively reactive state 12–24 weeks after operation. Intimate ceramic surface‐mesenchyme contacts without foreign body reactions supported the idea that alumina oxide ceramic tends to be incorporated into the body's physiological environment while metals are “excluded” by fibrous tissue layers of low biological activity. Corrosion on the ceramic surface was not detectable.