Error-processing abnormalities in pediatric anxiety and obsessive compulsive disorders.
Error-processing abnormalities in pediatric anxiety and obsessive compulsive disorders.
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DOI：
10.1017/s1092852915000036
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发表时间：
2015-08
期刊：
影响因子：
3.3
通讯作者：
Taylor SF
中科院分区：
文献类型：
--
作者：
Fitzgerald KD;Taylor SF
焦虑和强迫症是最早发生的精神病理学之一，可能源于错误处理的神经网络的非典型成熟。心理学模型交替地表明，过度检测错误，过度关心错误或错误未能引起调节控制可能与焦虑的表达有关。在这篇综述文章中，焦虑和强迫症的错误处理的潜在相关性的神经生理和功能磁共振成像（fMRI）研究的背景下，证明改变了大脑的反应，在儿童和成人患者的错误。最后，从现存的文献中得出关于焦虑和强迫症的发育敏感机制的假设，并讨论了临床翻译的途径。
Anxiety and obsessive compulsive disorders are among the earliest occurring psychopathology and may derive from atypical maturation of neural networks for error processing. Psychological models have alternately suggested that overdetection of errors, excessive caring about errors or failure of errors to elicit regulatory control could associate with the expression of anxiety. In this review article, the potential relevance of error processing for anxiety and obsessive compulsive disorders is described in the context of neurophysiological and functional magnetic resonance imaging (fMRI) research demonstrating altered brain response to errors in pediatric and adult patients. Finally, hypotheses about developmentally sensitive mechanisms of anxiety and obsessive compulsive disorders are drawn from the extant literature, and avenues for clinical translation are discussed.