Characterization of a uterine-type oxytocin receptor in the rat hippocampus.
Characterization of a uterine-type oxytocin receptor in the rat hippocampus.
复制标题
大鼠海马子宫型催产素受体的表征。
DOI：
10.1073/pnas.80.21.6713
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发表时间：
1983
影响因子：
11.1
通讯作者：
Dreifuss,JJ
中科院分区：
文献类型：
--
作者：
Mühlethaler,M;Sawyer,WH;Manning,MM;Dreifuss,JJ
细胞外记录来自海马片中的一类非锥体神经元。在浴缸中加入浓度为1 NM或更大的催产素，可使这些细胞兴奋。这种作用被一种合成的结构类似物可逆地拮抗，这种结构类似物可以阻断催产素的外周内分泌效应。催产素的作用被一种选择性催产素激动剂和效力较低的后叶加压素和其他结构类似物模拟。催产素、后叶加压素和这些类似物在海马区的效力与它们的子宫紧张性活动密切相关，但与它们的升压素或抗利尿活性无关。这些数据表明，有一类海马神经元被赋予催产素受体，类似于子宫平滑肌细胞的受体。
Extracellular recordings were obtained from a class of nonpyramidal neurones in hippocampal slices. Oxytocin applied to the bath at concentrations of 1 nM or greater excited these cells. This effect was reversibly antagonized by a synthetic structural analogue known to block the peripheral endocrine effects of oxytocin. The effect of oxytocin was mimicked by a selective oxytocic agonist and, with less potency, by vasopressin and by other structural analogues. The potencies of oxytocin, vasopressin, and of these analogues in the hippocampus correlated well with their uterotonic activities but not with their vasopressor or antidiuretic activities. The data suggest that a class of hippocampal neurones is endowed with receptors for oxytocin that are similar to those of uterine smooth muscle cells.