An interview with Douglas N. Robinson-Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
An interview with Douglas N. Robinson-Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
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对美国马里兰州巴尔的摩道格拉斯·N·罗宾逊-约翰·霍普金斯医学院的采访。
DOI：
10.1002/cm.21817
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Robinson,DouglasN
中科院分区：
文献类型：
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作者：
Trevorrow,Paul;Robinson,DouglasN
我们的核心研究兴趣涉及细胞形状控制和细胞形状变化的基本原理。例如，这背后的想法是，如果我们的细胞没有能力为它们的每一种功能呈现出非常特定的形状，那么生物学就不可能以我们所喜欢的方式发生。如果我们的细胞不能形成不同的结构，我们就只是一团细胞。但是，它们必须能够动态地改变这些结构，它们的形状，等等，以便能够进行细胞分裂和形态发生，在那里它们从一种细胞类型转变为另一种细胞类型，然后最终产生组织，器官和器官系统。我想指出的另一个角度是：过去一百多年来，谁更擅长诊断疾病？病理学家！有人进去看组织然后说：
Our research interest at its core pertains to the fundamentals of cell shape control and cell shape change. The idea behind that, for instance, is, if our cells did not have the ability to take on and assume very specific shapes for each of their functions, then biology could not happen the way we all enjoy it. We would just be blobs of cells if our cells could not form different structures. But then, they have to be able to dynamically change those structures, their shapes, and so forth, in order to be able to do things like cell division and morphogenesis, where they transition from one cell type to another and then eventually give rise to things like tissues, organs, and organ systems. The other angle that I would like to point out is: who has been better at diagnosing disease for the past 100 plus years? A pathologist! Someone who goes in and looks at tissue and goes: