A requirement for memory retrieval during and after long-term extinction learning.
A requirement for memory retrieval during and after long-term extinction learning.
复制标题
长期消退学习期间和之后记忆检索的要求。
DOI：
10.1073/pnas.0502315102
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Thomas,StevenA
中科院分区：
文献类型：
--
作者：
Ouyang,Ming;Thomas,StevenA
当前的学习理论是基于这样一种观点，即学习是由期望和经验之间的差异驱动的（德尔塔规则）。在绝灭中，一个人学习到某些期望不再适用。在这里，我们测试潜在的有效性，通过操纵记忆检索（从而期望）在灭绝学习的德尔塔规则。肾上腺素能信号传导对于情境性恐惧的限时恢复（但不是获得或巩固）至关重要。使用遗传和药理学方法来操纵肾上腺素能信号，我们发现，长期灭绝需要记忆检索，但不条件反应。对肾上腺素能系统的相同操作不会影响记忆提取，也不会改变消退。研究结果为学习理论中的delta规则提供了有力的支持。此外，灭绝是敏感的肾上腺素操纵的时间表明，记忆检索期间发生的模型，并在几个小时后，灭绝学习，以巩固长期的灭绝记忆。
Current learning theories are based on the idea that learning is driven by the difference between expectations and experience (the delta rule). In extinction, one learns that certain expectations no longer apply. Here, we test the potential validity of the delta rule by manipulating memory retrieval (and thus expectations) during extinction learning. Adrenergic signaling is critical for the time-limited retrieval (but not acquisition or consolidation) of contextual fear. Using genetic and pharmacologic approaches to manipulate adrenergic signaling, we find that long-term extinction requires memory retrieval but not conditioned responding. Identical manipulations of the adrenergic system that do not affect memory retrieval do not alter extinction. The results provide substantial support for the delta rule of learning theory. In addition, the timing over which extinction is sensitive to adrenergic manipulation suggests a model whereby memory retrieval occurs during, and several hours after, extinction learning to consolidate long-term extinction memory.
喂食毛果芸香碱的大鼠体内的恶性肿瘤。
影响因子：
8.8
作者：
M. Rao;J. Reddy
通讯作者：
J. Reddy
实验性肝癌发生过程中环氧化物水解酶的免疫组织化学研究。
影响因子：
11.2
作者：
Enomoto,K;Ying,TS;Griffin,MJ;Farber,E
通讯作者：
Farber,E