Study of the effectiveness of influenza vaccination in the elderly in the epidemic of 1989-90 using a general practice database
Study of the effectiveness of influenza vaccination in the elderly in the epidemic of 1989-90 using a general practice database
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DOI：
10.1017/s095026880005874x
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发表时间：
1995-12-01
影响因子：
4.2
通讯作者：
Swan, AV
中科院分区：
文献类型：
--
作者：
Fleming, DM;Watson, JM;Swan, AV
流感疫苗在预防严重疾病和死亡方面的有效性是在1989-90年流感流行期间在老年人口中确定的。使用计算机全科医生记录对近10000名55岁及以上的患者进行了一项回顾性队列研究，在调整了潜在的混杂因素后，最近的免疫接种对死亡的保护效果为75%(95%可信区间：21-92%)。保护性似乎不随年龄或潜在慢性病的存在而变化。由于流感的并发症最常见于那些患有潜在慢性病的人，研究结果与英国使用流感疫苗的推荐政策是一致的。有必要进一步开展工作，以确定将免疫扩大到其他群体的成本效益。
The effectiveness of influenza vaccination in preventing serious illness and death was determined in an elderly population during the influenza epidemic of 1989-90. A retrospective cohort study was carried out using computerized general practitioner records on nearly 10000 patients aged 55 years and over, After adjustment for potential confounding factors, recent immunization was found to have a protective effect of 75% (95% confidence intervals: 21-92%) against death. Protection did not appear to vary with either age or the presence of underlying chronic disease. As the complications of influenza are most common in those with underlying chronic disease, the study findings are consistent with the recommended policy for the use of influenza vaccine in the UK. Further work is necessary to determine the cost-effectiveness of extending immunization to other groups.