Activation of Coagulation and Fibrinolysis in Heatstroke
Activation of Coagulation and Fibrinolysis in Heatstroke
复制标题
中暑时凝血和纤维蛋白溶解的激活
DOI：
10.1055/s-0038-1650685
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发表时间：
1996
影响因子：
6.7
通讯作者：
D. Prost
中科院分区：
文献类型：
--
作者：
A. Bouchama;F. Bridey;Muhammad M. Hammami;C. Lacombe;Essam Al;Yazid Al;Frédéric Combe;S. Al;D. Prost
出血性和广泛的微血栓形成在中暑中很常见。为了评估中暑患者凝血功能的早期阶段，对16例中暑患者（平均±SE直肠温度42.3±0.2°C）降温前后的凝血酶-抗凝血酶III （TAT）、纤维蛋白单体、纤溶酶a2-抗纤溶酶（PAP）、纤溶酶原和d -二聚体进行了测定，并与8例热应激和23例正常对照进行了比较。与正常对照相比，TAT、纤维蛋白单体、PAP和d -二聚体（中位数（范围））升高至16.5（4-1000）比3.5 （2-7.2）Μg/l p<0.001,16（4-113）比2 (2-9)nM p<0.001；3300 (1000-36500) vs 255 （136-462） Μg/l p<0.001, 0.72 (0.22-64.8) vs 0.15 （0.05-0.25） Μg/ml p<0.01。纤溶酶原降低至81% (34-106)；PAP、TAT、D-Dimer与热疗相关（r = 0.577, p = 0.02; r = 0.635, p = 0.01; r = 0.76, p = 0.003）。降温后PAP降至545 （260-850）Μg/1 p<0.005， TAT降至10 (6-70)|ig/l，纤维蛋白单体22 (18-86)nM保持不变。热应激对照组各项指标均有轻微但显著的升高。在中暑中，凝血和纤溶的激活发生得早，而且是深刻和持续的。冷却似乎只减弱纤维蛋白溶解的激活，然而，这需要在更大的研究人群中得到证实。
Summary Hemorrhagic diathesis and widespread microthrombosis are common in heatstroke. To assess the early stages of coagulopathy in heatstroke, thrombin-antithrombin III (TAT), fibrin monomers, plasmin-a2-antiplasmin (PAP), plasminogen and D-Dimer were measured in 16 heatstroke patients (means ± SE rectal temperature 42.3 ± 0.2° C) pre- and postcooling and compared with 8 heatstressed and 23 normal controls. Comparing heatstroke patients with normal controls, TAT, fibrin monomers, PAP and D-Dimer were elevated to (median (range)) 16.5 (4-1000) versus 3.5 (2-7.2) Μg/l p<0.001,16 (4-113) versus 2 (2-9) nM p<0.001; 3300 (1000-36500) versus 255 (136-462) Μg/l p<0.001 and 0.72 (0.22-64.8) versus 0.15 (0.05-0.25) Μg/ml p<0.01 respectively. Plasminogen decreased to 81% (34-106); PAP, TAT and D-Dimer correlated significantly with hyperthermia (r = 0.577, p = 0.02; r = 0.635, p = 0.01; r = 0.76, p = 0.003). Postcooling PAP decreased to 545 (260-850) Μg/1 p<0.005, TAT 10 (6-70) |ig/l, and fibrin monomers 22 (18-86) nM remained unchanged. Heatstressed controls showed mild but significant increase in all markers. Activation of coagulation and fibrinolysis occurs early and is profound and sustained in heatstroke. Cooling seems to attenuate the activation of fibrinolysis only, however, this requires confirmation in a larger study population.
抗凝血酶 III 和抗凝血酶 III 复合物的体内代谢。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Shifman,MA;Pizzo,SV
通讯作者：
Pizzo,SV
影响因子：
15.9
作者：
LEVI, M;TENCATE, H;ROSENBERG, RD
通讯作者：
ROSENBERG, RD