SENSORY-MOTOR NERVE CROSSES IN THE RAT
SENSORY-MOTOR NERVE CROSSES IN THE RAT
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DOI：
10.1152/jn.1945.8.3.173
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发表时间：
1945-01-01
影响因子：
2.5
通讯作者：
EDDS, MV
中科院分区：
文献类型：
--
作者：
WEISS, P;EDDS, MV
感觉神经纤维再生到运动残肢和肌肉的问题已经在大鼠身上重新进行了研究。动脉套防止了杂散纤维的侵入。感觉纤维，没有选择性的迹象，通过运动神经轻松再生，并以密集的树枝遍布肌肉。再生后，交叉神经的电刺激在大多数情况下引起肌肉收缩。然而，分别刺激背根和腹根，或去传出的周围神经，证明这些肌肉收缩仅由交叉中包括的腹根纤维介导。感觉纤维没有形成传递连接。被感觉纤维完全包围的肌纤维经历了同样程度的萎缩和退化，就好像没有神经纤维存在一样。混合再神经支配的肌肉比运动纤维和感觉纤维的比例恢复得更大。显然，每根运动纤维都承受着额外的负荷；但是这种运动单元的扩展是有限的。组织学上，有神经支配的肌肉纤维群与退化的、无神经支配的肌肉纤维群形成鲜明的对比，表明运动神经纤维倾向于保持聚集。在任何情况下，没有任何迹象表明，功能无用的神经纤维吸收，直到8岁。手术后。
The problem of the regeneration of sensory nerve fibers into motor stumps and muscles has been re-examined in rats. Arterial sleeves prevented the intrusion of stray fibers. The sensory fibers, exhibiting no sign of selectivity, regenerated through the motor nerve with ease and pervaded the muscle with dense arborizations. After regeneration, electric stimulation of the crossed nerve in most cases caused muscle contraction. Stimulation of the dorsal and ventral roots separately, or of the de-efferented peripheral nerve, however, proved that these muscle contractions were mediated only by ventral root fibers included in the cross. No transmissive connections were formed by sensory fibers. Muscle fibers surrounded by sensory fibers exclusively underwent the same degree of atrophy and degeneration as if no nerve fibers were present. Muscles with mixed reinnerva-tion recovered wt. to a greater extent than in proportion to the ratio of motor to sensory fibers present. Evidently, each motor fiber takes on an excess load; but this expansiveness of the motor unit is limited. Histologically, the innervated muscle fiber groups are rather sharply set off against the degenerated, uninnervated ones, indicating a tendency of the motor nerve fibers to stay assembled. In no case was there any sign of resorption of functionally useless nerve fibers as late as 8 mos. post operative.