Effect of treatment of gestational diabetes mellitus on obesity in the next generation.
Effect of treatment of gestational diabetes mellitus on obesity in the next generation.
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DOI：
10.2337/dc09-1810
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发表时间：
2010-05
期刊：
影响因子：
16.2
通讯作者：
Crowther CA
中科院分区：
文献类型：
--
作者：
Gillman MW;Oakey H;Baghurst PA;Volkmer RE;Robinson JS;Crowther CA
妊娠期糖尿病(GDM)可能会导致后代肥胖。目的是评估轻度妊娠期糖尿病治疗对4至5岁儿童BMI的影响。参与者是199名母亲和她们的孩子，她们参加了一项关于妊娠期轻度妊娠期糖尿病治疗的随机对照试验。在南澳大利亚州的一个全州监测项目中，训练有素的护士在学龄前探视时测量了儿童的身高和体重。主要结果衡量标准是基于国际肥胖工作组标准的特定年龄和性别的BMI Z评分。在母亲为干预组的94名儿童中，出生时巨大儿(Birth Weight≥，4000g)的患病率为5.3%，在常规护理对照组的10 5名儿童中，巨大儿的患病率为21.9%。在4~5岁时，干预组的平均(SD)BMI Z得分为0.49(1.20)，对照组为0.41(1.40)。治疗组之间的差异为0.08(95%CI−为0.29至0.44)，这一估计在调整母亲种族、产次、年龄和社会经济指数后变化最小(0.08[−0.29至0.45])。评估体重指数≥第85百分位数，而不是连续的体重指数Z得分，得到类似的空结果。虽然妊娠期糖尿病的治疗大大减少了出生时的巨大儿，但它并没有导致4至5岁时体重指数的变化。
Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. Participants were 199 mothers who participated in a randomized controlled trial of the treatment of mild GDM during pregnancy and their children. Trained nurses measured the height and weight of the children at preschool visits in a state-wide surveillance program in the state of South Australia. The main outcome measure was age- and sex-specific BMI Z score based on standards of the International Obesity Task Force. At birth, prevalence of macrosomia (birth weight ≥4,000 g) was 5.3% among the 94 children whose mothers were in the intervention group, and 21.9% among the 105 children in the routine care control group. At 4- to 5-years-old, mean (SD) BMI Z score was 0.49 (1.20) in intervention children and 0.41 (1.40) among controls. The difference between treatment groups was 0.08 (95% CI −0.29 to 0.44), an estimate minimally changed by adjustment for maternal race, parity, age, and socio-economic index (0.08 [−0.29 to 0.45]). Evaluating BMI ≥85th percentile rather than continuous BMI Z score gave similarly null results. Although treatment of GDM substantially reduced macrosomia at birth, it did not result in a change in BMI at age 4- to 5-years-old.
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