Studies on a high encapsulation of colchicine by a niosome system
Studies on a high encapsulation of colchicine by a niosome system
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DOI：
10.1016/s0378-5173(02)00301-0
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发表时间：
2002-09-05
影响因子：
5.8
通讯作者：
Li, K
中科院分区：
文献类型：
--
作者：
Hao, YM;Zhao, FL;Li, K
以司盘60和胆固醇为原料，采用蒸发-超声法制备高包封率的水溶性药物囊泡。相应的囊泡在至少40天内显示出良好的稳定性。选择秋水仙碱作为模型药物用于检查这些囊泡的包封能力。考察了表面活性剂结构、脂质含量、药物含量、胆固醇含量等因素对包封率的影响。本文还讨论了其内在原因。结果表明，Span 60是四种Span中最理想的表面活性剂。此外，秋水仙碱和5-氟尿嘧啶（5-FU）从囊泡体外释放的研究显示出延长的释放曲线，研究超过24小时。结果表明，以这种方式制备的囊泡不仅具有高的包封能力，而且有望减少药物的副作用。该方法在可溶性药物的包封领域有着广阔的应用前景。(C)2002爱思唯尔科技有限公司。保留所有权利。
To prepare niosomes which have high encapsulation capacity for soluble drugs, starting from Span 60 and cholesterol, an improved method, evaporation-sonication method, was proposed. The corresponding niosomes show a good stability at least 40 days. Colchicine was chosen as a model drug for examining the capsulation capacity of these niosomes. To obtain the highest encapsulation efficiency, several factors including the structure of surfactant, level of lipid, content of drug and cholesterol were investigated and optimized. The inner cause was also discussed. The results indicate that the Span 60 is the most ideal surfactant among four kinds of Span. Furthermore, the release studies of colchicine and 5-fluorouracil (5-FU) in vitro from niosomes exhibited a prolonged release profile as studied over a period of 24 h. The results demonstrated that niosomes prepared in this way not only have high encapsulation capacity but also is expected that side effects of drugs may be reduced. It still suggests that this method may be used extensively in the field of encapsulation soluble drugs. (C) 2002 Elsevier Science B.V. All rights reserved.