Role of cartilage collagen fibrils networks in knee joint biomechanics under compression
Role of cartilage collagen fibrils networks in knee joint biomechanics under compression
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DOI：
10.1016/j.jbiomech.2008.09.033
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发表时间：
2008-12-05
影响因子：
2.4
通讯作者：
Hurtig, M.
中科院分区：
文献类型：
--
作者：
Shirazi, R.;Shirazi-Adl, A.;Hurtig, M.
膝关节软骨和半月板中的胶原纤维网络在内容和结构上从一个区域到另一个区域发生变化。在抵制紧张局势的同时，它们会影响全球联合反应以及地方压力，特别是在短期内。为了研究纤维网络在膝关节力学特别是软骨响应中的作用，建立了一种新的膝关节模型，该模型结合了软骨和半月板纤维网络以及软骨的深度相关特性。模拟软骨中垂直于软骨下骨的深层纤维或平行于表面的表层纤维的缺失，以及软骨下交界处软骨的局部断裂或加载区域的局部浅纤维损伤，研究了关节在高达2000N压缩下的响应。软骨中的深层垂直纤维网络通过减少大应变(从最大的102%减少到38%)，在加强(10%)整体反应和保护软骨方面发挥关键作用，特别是在软骨下交界处。浅层水平纤维主要保护组织免受表层过度应变(27%至8%)的影响。局部软骨在底部分裂，破坏了受影响区域垂直纤维的正常功能，导致更高的应力。在瞬间压缩下，深层纤维和较小程度的浅纤维在软骨反应中起主导作用。任何试图修复或再生涉及部分或全部厚度骨软骨移植的软骨缺损的治疗方法都应该考虑到胶原纤维网络的关键作用和组织的苛刻机械环境。(C)2008爱思唯尔有限公司，版权所有。
Collagen fibrils networks in knee Cartilage and menisci change in content and structure from a region to another. While resisting tension, they influence global joint response as well as local strains particularly at short-term periods. To investigate the role of fibrils networks in knee joint mechanics and in particular cartilage response, a novel model of the knee joint is developed that incorporates the cartilage and meniscus fibrils networks as well as depth-dependent properties in cartilage. The joint response under up to 2000 N compression is investigated for conditions Simulating the absence in cartilage of deep fibrils normal to subchondral bone or superficial fibrils parallel to surface as well as localized split of cartilage at subchondral junction or localized damage to Superficial fibrils at loaded areas. Deep vertical fibrils network in Cartilage play a crucial role in stiffening (by 10%) global response and protecting cartilage by reducing large strains (from maximum of 102% to 38%), in particular at subchondral junction. Superficial horizontal fibrils protect the tissue mainly from excessive Strains at Superficial layers (from 27% to 8%). Local cartilage split at base disrupts the normal function of vertical fibrils at the affected areas resulting in higher strains.Deep fibrils, and to a lesser extent superficial fibrils, play dominant mechanical roles in cartilage response Under transient compression. Any treatment modality attempting to repair or regenerate cartilage defects involving Partial Or full thickness osteochondral grafts should account for the crucial role of collagen fibrils networks and the demanding mechanical environment of the tissue. (C) 2008 Elsevier Ltd, All rights reserved.