Histiocytosis-X.
Histiocytosis-X.
复制标题
组织细胞增多症-X。
DOI：
10.1056/nejm198101153040304
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Parkman,R
中科院分区：
文献类型：
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作者：
Osband,ME;Lipton,JM;Lavin,P;Levey,R;Vawter,G;Greenberger,JS;McCaffrey,RP;Parkman,R
17例组织细胞增多症- x患者中有12例免疫异常，表现为循环淋巴细胞对培养的人成纤维细胞自发产生细胞毒性或对自体红细胞产生抗体。患者的T淋巴细胞也明显缺乏组胺H2表面受体，提示抑制细胞缺乏。在小牛胸腺粗提取物中孵育后，淋巴细胞异常在体外得到逆转，因此所有17例患者均每日肌内注射该提取物。通过这种疗法，10名患者进入了完全缓解期，其反应至少与接受化疗的历史对照组一样好。阳性的临床反应与t细胞组胺H2受体的数量增加到正常水平以及其他免疫异常的纠正有关。这项初步研究的结果证明了胸腺提取物的更大的前瞻性临床试验和进一步研究组织细胞增多症- x的免疫调节机制。[J] .中华医学杂志。1981;34(4):346 - 353。
Twelve of 17 patients with histiocytosis-X were immunologically abnormal, as shown by the presence of circulating lymphocytes spontaneously cytotoxic to cultured human fibroblasts or of antibody to autologous erythrocytes. The patients also had a notable lack of histamine H2 surface receptors on their T lymphocytes, suggesting a suppressor-cell deficiency. The lymphocyte abnormalities were reversed in vitro after incubation in a crude extract of calf thymus gland, and therefore all 17 patients were treated with daily intramuscular injections of this extract. With this therapy, 10 patients entered complete remission — a response at least as good as that observed in historical controls treated with chemotherapy. A positive clinical response was associated with an increase in the number of T-cell histamine H2 receptors to normal levels and with correction of the other immunologic abnormalities. The results of this preliminary study justify a larger prospective clinical trial of thymic extract and further investigation of the immunoregulatory mechanisms in histiocytosis-X. (N Engl J Med. 1981; 304:146–53.)