Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients
Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients
复制标题
DOI：
10.1038/sj.onc.1203713
复制
发表时间：
2000-08-03
期刊：
影响因子：
8
通讯作者：
Dejean, A
中科院分区：
文献类型：
--
作者：
Marchio, AS;Pineau, P;Dejean, A
为了鉴别与肝细胞癌的病因相关的染色体异常，我们对34例非肝硬变患者的肝组织进行了比较基因组杂交(CGH)分析，这些肝细胞来自血清中均为阴性的乙肝病毒和丙型肝炎病毒。这一结果仅与先前根据乙肝病毒感染阳性挑选的50例肝癌的分析结果相比，在病毒阴性病例中发现的大多数异常(染色体臂1p、8p、6q、13q和14q的丢失和1q、8q、6p和17q的获得)与之前的分析结果相似。相比之下，在非病毒性肝细胞癌样本中，4q、16q和17p的丢失显著减少(平均40%)，这表明这些异常与乙肝病毒感染密切相关。因此，除了常见的致癌途径外，一系列的改变可能优先促进病毒诱导的致癌作用。在一项对10例罕见的肝细胞癌亚型纤维板层癌的平行CGH研究中发现，在7例信息性病例中，染色体臂IQ的增加，该区域也优先在非纤维板层肿瘤(58%)中扩增，可能含有通常与肝癌发生有关的必要原癌基因。
To discriminate among the chromosomal abnormalities associated with the etiology of hepatocellular carcinoma (HCC), we performed a comparative genomic hybridization (CGH) analysis on 34 HCCs resected on noncirrhotic livers from patients serologically negative for both hepatitis B (HBV) and C (HCV) viruses. The results mere compared to those of a previous analysis of 50 HCCs selected on the basis of their positivity for HBV infection, The majority of the abnormalities found in the HBV positive cases (losses of chromosome arms 1p, 8p, 6q, 13q and 14q and gains of 1q, 8q, 6p and 17q) were similarly detected in the virus negative specimens. In contrast, a significant decrease (40% on average) was observed for losses at 4q, 16q and 17p in non-viral HCC samples, suggesting that these abnormalities are tightly associated with HBV infection. Thus, in addition to a common pathway towards malignancy, a subset of alterations may preferentially contribute to virus-induced carcinogenesis. In a parallel CGH study of 10 fibrolamellar carcinomas, a rare subtype of HCC, me found in sis out of the seven informative cases, gains of chromosome arm Iq, This region, which is also preferentially amplified in non fibrolamellar tumors (58%), may contain an essential proto-oncogene commonly implicated in liver carcinogenesis.