DOES SUBSTANCE-P MEDIATE SLOW SYNAPTIC EXCITATION WITHIN MYENTERIC PLEXUS
DOES SUBSTANCE-P MEDIATE SLOW SYNAPTIC EXCITATION WITHIN MYENTERIC PLEXUS
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DOI：
10.1038/274387a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
NORTH, RA
中科院分区：
文献类型：
--
作者：
KATAYAMA, Y;NORTH, RA
P物质在中枢-6和外周- 7神经系统神经元中的广泛分布使人们认为它可能是神经元功能的重要调节剂。虽然当使用微离子电阻10-14时，P物质通常会刺激中枢神经元，但这种刺激相当缓慢，这可能不适合快速作用的神经递质11。在本报告中，我们发现P物质对肌肠神经元膜具有强大的去极化作用，这主要是由静息钾电导失活引起的。此外，在一些神经元中，我们观察到突触诱发的去极化具有时间过程和离子机制，与P物质产生的去极化相似。鉴于肌肠丛在神经末梢和多样性中含有P物质的证据，这一点特别有趣8,9。
THE widespread distribution of substance P within neurones of the central1-6and peripheral7-9nervous systems has led to the suggestion that it may be an important modulator of neuronal function. Although when applied by microiontophoresis10-14substance P usually excites central neurones, this excitation is rather slow and this may not be appropriate to the role of a rapidly acting neurotransmitter11. In this report we show substance P to have a powerful depolarising action on the membrane of myenteric neurones and that this is brought about primarily by an inactivation of resting potassium conductance. Furthermore, in several neurones we have observed synaptically evoked depolarisations which have a time course and ionic mechanism similar to the depolarisations produced by substance P. This is of particular interest in view of the evidence that the myenteric plexus contains substance P within nerve terminals and varicosities8, 9.