Early post‐operative intravenous tacrolimus in pediatric liver transplant recipients is not superior to oral tacrolimus
Early post‐operative intravenous tacrolimus in pediatric liver transplant recipients is not superior to oral tacrolimus
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小儿肝移植受者术后早期静脉注射他克莫司并不优于口服他克莫司
DOI：
10.1111/petr.13368
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发表时间：
2019
影响因子：
1.3
通讯作者：
Uemoto Shinji
中科院分区：
文献类型：
--
作者：
Sabra Tarek Abdelazeem;Okajima Hideaki;Yoshizawa Atsushi;Ogawa Eri;Okamoto Shinya;Osman Mohamed Abdelkader;Saad‐Eldin Yasser;Uemoto Shinji
我们的目的是比较静脉注射与口服TAC作为原发性免疫抑制剂在接受LT的儿科患者中的早期结果。这项回顾性研究纳入了2011年9月至2015年10月期间在我们机构接受LT并接受TAC -类固醇方案作为原发性免疫抑制剂的75名儿童。35名患者接受了TAC静脉注射，40名患者接受了TAC静脉注射。早期结果进行了评估和比较，包括ACR、EBV或CMV感染；肾脏不良反应；还有住院。比较移植后90天的结果显示，静脉注射组的总病毒感染率（74%比40%P< 0.002）、EBV感染率（46%比17.5%P< 0.008）和CMV感染率（51%比30%P= 0.05）显著高于静脉注射组。两种方案对肾功能均无不良影响。两组间ACR发生率和严重程度、血清肌酐浓度和住院时间均无差异。两组患者和移植物3个月和1年生存率无显著差异。与p.o.治疗相比，静脉注射高浓度TAC对移植后ACR的发生率和严重程度没有有益的影响，但增加了儿童LT病毒感染的发生率。
We aimed to compare the early results of i.v. with p.o. TAC as a primary immunosuppressant in pediatric patients undergoing LT. This retrospective study enrolled 75 children who underwent LT and received TAC‐steroid regimens as a primary immunosuppressant between September 2011 and October 2015 at our institution. Thirty‐five recipients received TAC i.v. and 40 received TAC p.o. Early results were evaluated and compared, including ACR, EBV, or CMV infection; renal adverse effects; and hospital stay. Comparisons of 90‐day post‐transplant results showed that the rates of overall viral (74% vs 40%P< 0.002), EBV (46% vs 17.5%P< 0.008), and CMV (51% vs 30%P= 0.05) infections were significantly higher in the i.v. than in the p.o. group. Neither regimen has any adverse effects on renal function. There were no between‐group differences in ACR incidence and severity, serum creatinine concentration, and hospital stay. Patient and graft survival rates at 3 months and 1 year did not differ significantly between the two groups. Compared with p.o. treatment, i.v. administration of high TAC concentration did not have beneficial post‐transplant effects on ACR incidence and severity, while increasing the incidence of viral infections in pediatric LT.
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影响因子：
8.8
作者：
Boudjema, K.;Camus, C.;Bellissant, E.
通讯作者：
Bellissant, E.
原发性原位肝移植后排斥反应与 FK 506 剂量、FK 506 水平和类固醇的相关性。
影响因子：
0.9
作者：
Jain,AB;Todo,S;Fung,JJ;Venkataramanan,R;Day,R;Bryant,J;Abu-Elmagd,KM;Alessiani,M;Takaya,S;Tzakis,A
通讯作者：
Tzakis,A
影响因子：
9
作者：
Jain, A;Reyes, J;Fung, J
通讯作者：
Fung, J
影响因子：
0.9
作者：
Lu, B. R.;Park, K. T.;Berquist, W. E.
通讯作者：
Berquist, W. E.
移植儿科患者巨细胞病毒病毒载量与他克莫司和西罗莫司水平之间的相关性。
影响因子：
0.9
作者：
H. Reyes;J. Sánchez;G. Varela;J. C. Romo;A. Morales;E. Fuentes;I. Parra;Graciela Ramírez;B. López
通讯作者：
B. López