Relation of B-Type Natriuretic Peptide Levels to Body Mass Index After Comprehensive Lifestyle Changes
Relation of B-Type Natriuretic Peptide Levels to Body Mass Index After Comprehensive Lifestyle Changes
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DOI：
10.1016/j.amjcard.2010.01.016
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发表时间：
2010-06-01
影响因子：
2.8
通讯作者：
Ornish, Dean
中科院分区：
文献类型：
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作者：
Chainani-Wu, Nita;Weidner, Gerdi;Ornish, Dean
横断面研究报告了B型利钠肽（BNP）与体重指数（BMI）的负相关性。我们评估了BMI的变化是否与BNP的变化相关。进行了一项生活方式干预（低脂、全食物饮食、运动、压力管理和社会支持）的巢式前瞻性队列研究。在基线和3个月时测量BNP、BMI和其他生物标志物。共纳入131例受试者，其中56例患有冠心病（CHD），75例具有CHD危险因素和/或糖尿病的高危受试者。3个月时，平均BMI下降（34.4至31.7 kg/m2，p
Cross-sectional studies have reported inverse associations of B-type natriuretic peptide (BNP) with the body mass index (BMI). We evaluated whether changes in the BMI are associated with changes in BNP. A nested prospective cohort study of a lifestyle intervention (low-fat, whole-foods diet, exercise, stress management, and social support) was conducted. BNP, BMI, and other biomarkers were measured at baseline and 3 months. A total of 131 subjects, 56 with coronary heart disease (CHD) and 75 at high risk, with CHD risk factors and/or diabetes mellitus, were enrolled. At 3 months, the mean BMI had decreased (34.4 to 31.7 kg/m(2), p