Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men.
Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men.
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居住在健康社区的日本男性的饮酒和大脑形态测量。
DOI：
10.1016/j.alcohol.2020.11.006
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Co-c
中科院分区：
文献类型：
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作者：
Syaifullah,AliHaidar;Shiino,Akihiko;Fujiyoshi,Akira;Kadota,Aya;Kondo,Keiko;Ito,Takahiro;Segawa,Hiroyoshi;Moniruzzaman,Mohammad;Waki,Takashi;Miyagawa,Naoko;Tooyama,Ikuo;Ueshima,Hirotsugu;Miura,Katsuyuki;SESSAResearchGroup;Co-c
饮酒的临床影响已被广泛研究；然而，它对表面健康的社区居民大脑结构的影响仍不清楚。因此，我们使用基于体素的形态测量（VBM）研究了居住在社区的日本男性饮酒量与大脑灰质体积（GMV）之间的关系。我们从日本滋贺县的一个人口队列中招募了年龄在 40 至 79 岁之间、认知能力完好的日本男性。 2010-2014 年，平均在获得人口和医疗信息 2 年后进行脑磁共振成像。对 639 名男性进行了多元线性回归分析，以阐明饮酒量与 GMV 之间的关系。 VBM 统计数据通过无阈值聚类增强进行分析，族错误率 <0.05。获得的结果表明，饮酒量与较低的 GMV 相关。 VBM 分析显示，大量饮酒者（≥42 乙醇克/天）的海马旁、内嗅、扣带回、岛叶、颞叶、额叶皮质和小脑内的 GMV 低于不饮酒者。此外，饮酒与较高的白质病变体积有关。这些结果表明亚临床结构变化类似于酒精相关的神经系统疾病。
The clinical implications of alcohol consumption have been extensively examined; however, its effects on brain structures in apparently healthy community-dwellers remain unclear. Therefore, we investigated the relationship between alcohol consumption and brain gray matter volume (GMV) in community-dwelling Japanese men using voxel-based morphometry (VBM). We recruited cognitively intact Japanese men, aged 40–79 years, from a population-based cohort in Shiga, Japan. Brain magnetic resonance imaging was performed, on average, 2 years after demographic and medical information was obtained in 2010–2014. A multivariable linear regression analysis of 639 men was conducted to elucidate the relationship between the amount of alcohol consumed and GMV. VBM statistics were analyzed by threshold-free cluster enhancement with a family-wise error rate of <0.05. The results obtained demonstrated that the amount of alcohol consumed was associated with lower GMV. The VBM analysis showed lower GMV within the parahippocampal, entorhinal, cingulate, insular, temporal, and frontal cortices and cerebellum in very heavy drinkers (≥42 ethanol g/day) than in non-drinkers. Furthermore, alcohol consumption was associated with a higher white matter lesion volume. These results suggest subclinical structural changes similar to alcohol-related neurological diseases.