α-Pompilidotoxin (α-PMTX), a novel neurotoxin from the venom of a solitary wasp, facilitates transmission in the crustacean neuromuscular synapse
α-Pompilidotoxin (α-PMTX), a novel neurotoxin from the venom of a solitary wasp, facilitates transmission in the crustacean neuromuscular synapse
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α-Pompilidotoxin (α-PMTX) 是一种来自独居黄蜂毒液的新型神经毒素，可促进甲壳动物神经肌肉突触中的传输
DOI：
10.1016/s0304-3940(97)00849-5
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发表时间：
1997
影响因子：
2.5
通讯作者：
N. Kawai
中科院分区：
文献类型：
--
作者：
K. Konno;A. Miwa;H. Takayama;M. Hisada;Y. Itagaki;H. Naoki;T. Yasuhara;N. Kawai
在沙夫纳按蚊（Anoplius safnariensis）的毒液中发现了一种新的神经毒素，命名为α-pompilidotoxin（α-PMTX）。α-PMTX（10-100 μM）可显著增强龙虾步行腿神经肌肉突触的兴奋性和抑制性突触后电位。在突触部位记录兴奋性突触后电流（EPSC）表明α-PMTX可逆地和剂量依赖性地增强EPSC。α-PMTX可能主要作用于突触前膜，但该毒素的作用方式明显不同于其他已知的易化神经毒素，如α-latrotoxin、apamin或charybdotoxin。这种新的毒素将作为一个有用的工具，在神经科学的研究领域。
A new neurotoxin, named α-pompilidotoxin (α-PMTX) has been found in the venom of the solitary wasp Anoplius safnariensis. In the neuromuscular synapse of the lobster walking leg preparation, α-PMTX (10-100 μM) caused great enhancement of both the excitatory and inhibitory postsynaptic potentials. Recordings of the excitatory post synaptic currents (EPSCs) at the synaptic sites showed that α-PMTX reversibly and dose-dependently potentiates EPSCs. α-PMTX may act primarily on the presynaptic membrane but the mode of action of the toxin is clearly different from other known facilitatory neurotoxins, such as α-latrotoxin, apamin or charybdotoxin. This novel toxin will serve as a useful tool in the research field of neuroscience.
Omega-agatoxins：来自漏斗网蜘蛛（Agelenopsis aperta）毒液的两种亚型的新型钙通道拮抗剂。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Adams,ME;Bindokas,VP;Hasegawa,L;Venema,VJ
通讯作者：
Venema,VJ