Three rules govern thalamocortical connectivity of fast-spike inhibitory interneurons in the visual cortex.
Three rules govern thalamocortical connectivity of fast-spike inhibitory interneurons in the visual cortex.
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DOI：
10.7554/elife.60102
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发表时间：
2020-12-08
期刊：
影响因子：
7.7
通讯作者：
Swadlow HA
中科院分区：
文献类型：
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作者：
Bereshpolova Y;Hei X;Alonso JM;Swadlow HA
一些皮质神经元接受高度选择性的丘脑皮质（TC）输入，而另一些则没有。在这里，我们研究了单个丘脑神经元（外侧膝状核，LGN）与兔视觉皮层第4层的快速抑制中间神经元的连通性。我们展示了三个“规则”调节这种连接。这些规则涉及：(1)视网膜定位的精度，(2)中间神经元附近由LGN神经元的尖峰引起的突触后局部场电位的振幅，以及(3)中间神经元对强的、同步的LGN输入的响应延迟。我们发现，几乎所有的一阶快速脉冲中间神经元都能接收到附近突触的LGN轴突的输入，而不管它们的视觉反应特性如何。邻近的规则尖峰神经元则不是这样。我们的结论是，大量和高度混杂的TC输入到第4层快速脉冲抑制性中间神经元产生的反应特性非常适合于介导视觉皮层兴奋性神经元的快速、敏感和广泛调节的前馈抑制。
Some cortical neurons receive highly selective thalamocortical (TC) input, but others do not. Here, we examine connectivity of single thalamic neurons (lateral geniculate nucleus, LGN) onto putative fast-spike inhibitory interneurons in layer 4 of rabbit visual cortex. We show that three ‘rules’ regulate this connectivity. These rules concern: (1) the precision of retinotopic alignment, (2) the amplitude of the postsynaptic local field potential elicited near the interneuron by spikes of the LGN neuron, and (3) the interneuron’s response latency to strong, synchronous LGN input. We found that virtually all first-order fast-spike interneurons receive input from nearly all LGN axons that synapse nearby, regardless of their visual response properties. This was not the case for neighboring regular-spiking neurons. We conclude that profuse and highly promiscuous TC inputs to layer-4 fast-spike inhibitory interneurons generate response properties that are well-suited to mediate a fast, sensitive, and broadly tuned feed-forward inhibition of visual cortical excitatory neurons.