The developmental behavior genetics of drug involvement: overview and comments.
The developmental behavior genetics of drug involvement: overview and comments.
复制标题
药物参与的发育行为遗传学：概述和评论。
DOI：
10.1007/s10519-006-9070-y
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发表时间：
2006
影响因子：
2.6
通讯作者：
Zucker,RobertA
中科院分区：
文献类型：
--
作者：
Zucker,RobertA
本特刊的论文对物质使用、滥用和问题的遗传性的发展变化有共同的兴趣。许多研究都是纵向的，甚至那些横断面的研究都分析地关注遗传、共享和非共享的环境影响是恒定的还是在从开始使用到问题使用更恒定的时期内发生变化。这篇评论从发展精神病理学的角度概述了这项工作。研究结果与现有的关于物质使用障碍表观发生的纵向/发展文献有关，并指出了相似性和矛盾。提出了下一步工作的建议，包括需要增加药物滥用表型的区分，利用表型测量来描述异质性，以及更精确地定义共同和非共同环境责任基础上的具体环境变化。
The papers in this special issue have in common an interest in developmental variations in the heritability of substance use, abuse, and problems. A number of the studies are longitudinal, and even those that are cross-sectional are analytically focused on whether heritability, shared, and nonshared environmentality effects are constant or change over the period from onset of use to the time when problem use is more constant. This commentary provides an overview of the work from a developmental psychopathology perspective. Findings are linked to the existing longitudinal/developmental literature on the epigenesis of substance use disorders and similarities and contradictions are noted. Suggestions for next step work, involving the need for increased differentiation of the substance abuse phenotypes, the utilization of phenotypic measures that delineate heterogeneity of course, and more precise definition of the specific environmental variations that underlie shared and nonshared environmental liability, are provided.