Biomarkers as outcome predictors in subarachnoid hemorrhage--a systematic review.
Biomarkers as outcome predictors in subarachnoid hemorrhage--a systematic review.
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DOI：
10.3109/1354750x.2014.881418
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Simard JM
中科院分区：
文献类型：
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作者：
Hong CM;Tosun C;Kurland DB;Gerzanich V;Schreibman D;Simard JM
蛛网膜下腔出血（SAH）病死率高，许多患者出现迟发性神经功能缺损。生物标志物可以帮助识别高危患者，指导治疗/管理并改善结果。本综述的目的是总结SAH与预后相关的生物标志物。完成了一项电子数据库查询，包括对参考文献清单的进一步审查，以包括所有可能的人体研究。共鉴定出298件物品；审查了112项；纳入了55项研究。这篇综述详细介绍了与预后相关的SAH生物标志物。它为研究它们可能转化为SAH患者管理的研究提供了基础。
Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high-risk patients, guide treatment/management and improve outcome. The aim of this review was to summarize biomarkers of SAH associated with outcome. An electronic database query was completed, including an additional review of reference lists to include all potential human studies. A total of 298 articles were identified; 112 were reviewed; 55 studies were included. This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAH patients.