Lymphatics and bone
Lymphatics and bone
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DOI：
10.1016/j.humpath.2007.04.022
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发表时间：
2008-01-01
期刊：
影响因子：
3.3
通讯作者：
Athanasou, Nicholas A.
中科院分区：
文献类型：
--
作者：
Edwards, James R.;Williams, Kelly;Athanasou, Nicholas A.
关于骨中是否存在淋巴管存在争议。尽管骨中的淋巴管瘤已经被描述，但在任何其他良性或恶性骨肿瘤或正常人骨中的淋巴管还没有被确定的形态学鉴定。在这项研究中，我们通过免疫组织化学，使用2个特定的淋巴管内皮细胞标记物，LYVE-1和podoplanin，确定是否存在于正常骨和广泛的原发性和继发性骨肿瘤中的淋巴细胞。在正常骨中，LYVE-1（+）/podoplanin（+）淋巴管在皮质骨或松质骨中未被识别，但在骨膜上的结缔组织中可见。除淋巴管瘤、戈勒姆-斯托特病和血管内皮瘤外，局限于骨骼的原发性良性和恶性骨肿瘤（以及继发性癌）不含淋巴管。已经延伸穿过骨皮质的原发性和继发性骨肿瘤含有LYVE-1（+）/podoplanin（+）淋巴管，这些淋巴管似乎从周围软组织延伸到肿瘤中一小段距离。三例骨肉瘤已穿过骨皮质并发生淋巴结转移，均发现肿瘤内含有淋巴管。这些结果表明，淋巴循环不太可能在正常骨中的骨液运输中发挥作用，并且大多数局限于骨的原发性和继发性肿瘤不存在淋巴管。这些发现也表明，淋巴管生成并不参与大多数原发性骨肿瘤的疾病进展，并且癌性骨转移并不通过淋巴管发生。(c)2008年爱思唯尔公司All rights reserved.
There is controversy regarding whether lymphatic vessels are present or absent in bone. Although lymphangiomas have been described in bone, lymphatic vessels have not been identified morphologically with certainty in any other benign or malignant bone tumors or in normal human bone. In this study, we determined by immunohistochemistry, using 2 specific lymphatic endothelial cell markers, LYVE-1 and podoplanin, whether lymphatics are present in normal bone and a wide range of primary and secondary bone neoplasms. In normal bone, LYVE-1(+)/podoplanin(+) lymphatic vessels were not identified in cortical or cancellous bone but were seen in connective tissue overlying the periosteum. With the exception of lymphangioma, Gorham-Stout disease, and hemangioendothelioma, primary benign and malignant bone tumors (as well as secondary carcinomas) that were confined to bone did not contain lymphatic vessels. Primary and secondary bone tumors that had extended through the bone cortex contained LYVE-1(+)/podoplanin(+) lymphatic vessels that seemed to extend for a short distance from surrounding soft tissues into the tumor. Three cases of osteosarcoma that had extended through the bone cortex and had lymph node metastases were all found to contain lymphatic vessels within the tumor. These results indicate that the lymphatic circulation is unlikely to play a role in bone fluid transport in normal bone and that lymphatic vessels are absent from most primary and secondary tumors confined to bone. These findings also suggest that lymphangiogenesis is not involved in the disease progression of most primary bone tumors and that carcinomatous metastasis to bone does not occur via lymphatics. (c) 2008 Elsevier Inc. All rights reserved.