OBSERVATIONS ON THE SOCIAL BEHAVIOUR OF CELLS IN TISSUE CULTURE .1. SPEED OF MOVEMENT OF CHICK HEART FIBROBLASTS IN RELATION TO THEIR MUTUAL CONTACTS
OBSERVATIONS ON THE SOCIAL BEHAVIOUR OF CELLS IN TISSUE CULTURE .1. SPEED OF MOVEMENT OF CHICK HEART FIBROBLASTS IN RELATION TO THEIR MUTUAL CONTACTS
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DOI：
10.1016/0014-4827(53)90098-6
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发表时间：
1953-01-01
影响因子：
3.7
通讯作者：
HEAYSMAN, JEM
中科院分区：
文献类型：
--
作者：
ABERCROMBIE, M;HEAYSMAN, JEM
对液体培养基培养的鸡心脏成纤维细胞进行了观察，试图从统计学上分析每种成纤维细胞对彼此运动的相互影响。它们的运动速度是通过从文化电影中拍摄的放大剧照来分析的。分析表明：(a)在观察到的运动过程中，细胞的运动速度与与之接触的细胞数量之间存在显著的反比关系；(b)速度的瞬间增加与与另一个细胞取得或失去联系的行为有关。考虑到第一种关系与其他各种可变因素混淆的可能性，如培养年龄、周围细胞群密度或细胞与外植体的距离。虽然在某些条件下，这些因素可能对电池的速度有影响，但当它们的影响被消除时，速度和接触数之间的关系仍然存在。有人认为，这些现象是可以解释的。可能主要是由于细胞间的粘附作用。
Observations were made on chick heart fibroblasts in liquid medium cultures in an attempt to analyze statistically the mutual effects of each on the other''s movement. Their speed of movement is analyzed by means of enlarged stills taken from films of the cultures. Analysis shows that (a) there is a significant inverse relationship between the speed of movement of a cell and the numbers of cells with which it was in contact during the observed movement; (b) a momentary increase of speed is correlated with the act of gaining and of losing a contact with another cell. The possibility of the 1st relationship being confounded with various other variable factors such as age in culture, density of surrounding cell population, or distance of the cell from the explant is considered. Though under certain conditions these factors may have an effect on the speed of the cell, when their effect is removed the relationship between speed and number of contacts remains. It is suggested that the phenomena descr. may be, in the main, due to the effects of adhesions between the cells.