Gastrointestinal Nutrient Infusion Site and Eating Behavior: Evidence for A Proximal to Distal Gradient within the Small Intestine?
Gastrointestinal Nutrient Infusion Site and Eating Behavior: Evidence for A Proximal to Distal Gradient within the Small Intestine?
复制标题
胃肠道营养输注部位和饮食行为：小肠内远端梯度近端的证据？
DOI：
10.3390/nu8030117
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发表时间：
2016-02-26
期刊：
影响因子：
5.9
通讯作者：
Masclee AA
中科院分区：
文献类型：
--
作者：
Alleleyn AM;van Avesaat M;Troost FJ;Masclee AA
超重和肥胖症的迅速增加的流行需要新的战略，重点是预防和治疗这一重大的卫生保健问题。在寻找新的和有效的治疗方式超重的受试者，胃肠道（GI）道越来越被认为是一个有吸引力的目标，医疗和食品为基础的策略。营养物质进入小肠会激活所谓的肠道“刹车”，这是一种负反馈机制，不仅影响胃肠道更近端部分的功能，还影响饱腹感和食物摄入。最近的证据表明，所有三种常量营养素（蛋白质，脂肪和碳水化合物）都能够激活肠道制动，尽管程度不同，作用机制不同。这篇综述提供了一个详细的概述，目前的证据肠制动激活的三种常量营养素及其对胃肠道功能，饱腹感和食物摄入量的影响。此外，这些作用似乎取决于小肠中输注的区域和长度。根据观察到的肠制动激活之间的差异，提供了治疗方法的建议。
The rapidly increasing prevalence of overweight and obesity demands new strategies focusing on prevention and treatment of this significant health care problem. In the search for new and effective therapeutic modalities for overweight subjects, the gastrointestinal (GI) tract is increasingly considered as an attractive target for medical and food-based strategies. The entry of nutrients into the small intestine activates so-called intestinal “brakes”, negative feedback mechanisms that influence not only functions of more proximal parts of the GI tract but also satiety and food intake. Recent evidence suggests that all three macronutrients (protein, fat, and carbohydrates) are able to activate the intestinal brake, although to a different extent and by different mechanisms of action. This review provides a detailed overview of the current evidence for intestinal brake activation of the three macronutrients and their effects on GI function, satiety, and food intake. In addition, these effects appear to depend on region and length of infusion in the small intestine. A recommendation for a therapeutic approach is provided, based on the observed differences between intestinal brake activation.