Thermal ablation and immunotherapy for hepatocellular carcinoma: Recent advances and future directions.
Thermal ablation and immunotherapy for hepatocellular carcinoma: Recent advances and future directions.
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肝细胞癌的热消融和免疫治疗：最新进展和未来方向
DOI：
10.4251/wjgo.v13.i10.1397
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发表时间：
2021-10-15
影响因子：
3
通讯作者：
Xu HX
中科院分区：
文献类型：
--
作者：
Bo XW;Sun LP;Yu SY;Xu HX
肝细胞癌（Hepatocellular carcinoma，HCC）是世界上最常见的恶性肿瘤之一。热消融（TA）是不适合手术或肝移植的HCC患者的重要替代治疗方法。特别是对于小的和早期的HCC，TA可以被认为是一线治愈性治疗。然而，尽管TA设备和技术发展迅速，但局部和远处复发率仍然很高。免疫治疗是一种新型的系统性治疗方法，可以增强肝癌患者的抗肿瘤免疫应答，具有降低肿瘤复发和转移的潜力。局部TA联合全身免疫治疗HCC可能是提高TA疗效和控制复发的理想治疗方法。本文就TA、免疫治疗及其联合治疗肝癌的最新进展进行综述，并对联合治疗的局限性和未来的研究方向进行探讨。
Hepatocellular carcinoma (HCC) is one of most common cancers that cause death in the world. Thermal ablation (TA) is an important alternative treatment method for HCC patients who are not appropriate for surgery or liver transplantation. Particularly for small and early HCCs, TA can be considered as the first-line curative treatment. However, local and distant recurrence rates are still high even though the TA equipment and technology develop rapidly. Immunotherapy is a novel systemic treatment method to enhance the anti-tumor immune response of HCC patients, which has the potential to reduce the tumor recurrence and metastasis. The combination of local TA and systemic immunotherapy for HCCs may be an ideal treatment for enhancing the efficacy of TA and controlling the recurrence. Herein we summarize the latest progress in TA, immunotherapy, and their combination for the treatment of patients with HCC and discuss the limitations and future research directions of the combined therapy.
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[131I]美妥昔单抗治疗经皮射频消融术后肝细胞癌的随机试验。
影响因子：
10.3
作者：
Bian, Huijie;Zheng, Jia-Sheng;Chen, Zhi-Nan
通讯作者：
Chen, Zhi-Nan
DOI：
10.1016/j.jvir.2014.08.027
发表时间：
2014-11
期刊：
Journal of vascular and interventional radiology : JVIR
影响因子：
--
作者：
Ahmed M;Solbiati L;Brace CL;Breen DJ;Callstrom MR;Charboneau JW;Chen MH;Choi BI;de Baère T;Dodd GD 3rd;Dupuy DE;Gervais DA;Gianfelice D;Gillams AR;Lee FT Jr;Leen E;Lencioni R;Littrup PJ;Livraghi T;Lu DS;McGahan JP;Meloni MF;Nikolic B;Pereira PL;Liang P;Rhim H;Rose SC;Salem R;Sofocleous CT;Solomon SB;Soulen MC;Tanaka M;Vogl TJ;Wood BJ;Goldberg SN;International Working Group on Image-Guided Tumor Ablation;Interventional Oncology Sans Frontières Expert Panel;Technology Assessment Committee of the Society of Interventional Radiology;Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe
通讯作者：
Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe
影响因子：
3.7
作者：
Gameiro SR;Higgins JP;Dreher MR;Woods DL;Reddy G;Wood BJ;Guha C;Hodge JW
通讯作者：
Hodge JW
影响因子：
158.5
作者：
Finn, Richard S.;Qin, Shukui;Cheng, Ann-Lii
通讯作者：
Cheng, Ann-Lii
影响因子：
4.5
作者：
Dong, Hui;Li, Qiang;Kong, Da-Lu
通讯作者：
Kong, Da-Lu