ANTIGENIC SPECIFICITY OF BENZO(A)PYRENE-INDUCED SARCOMAS
ANTIGENIC SPECIFICITY OF BENZO(A)PYRENE-INDUCED SARCOMAS
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DOI：
10.1093/jnci/32.6.1229
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发表时间：
1964-01-01
期刊：
影响因子：
--
通讯作者：
FELDMAN, M
中科院分区：
文献类型：
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作者：
GLOBERSON, A;FELDMAN, M
苯并[1]诱导的C3H和C57BL小鼠肿瘤诱导对肿瘤特异性抗原的同种移植免疫反应。经一系列同种宿主转移后，原发瘤的抗原性高于同种肉瘤。显然，原发肿瘤移植瘤的进行性生长是由肿瘤的抗原性决定的。没有接纳正常宿主的肉瘤--例如早期移植世代的移植物--在移植到暴露于全身X光照射的动物身上时，即在免疫抑制的动物身上，会逐渐生长。抗原性的降低与肿瘤抗原的完全丧失无关。不再能免疫动物的肿瘤仍然容易受到早期移植一代的免疫原性移植物引发的免疫反应的影响。在同一动物体内同时应用致癌物2次所产生的2个肉瘤均具有明显的抗原性特异性。单个动物产生的肿瘤可能在(A)可移植性、(B)免疫原性和(C)抗原特异性方面有所不同。预先免疫的动物暴露在X射线照射下，然后进行移植试验，对于分析不可移植肿瘤的抗原特异性是最有用的。对起源于C3H的肉瘤在(C3H×C57BL)F1中进行抗原性测试的实验表明，对某些肿瘤缺乏明显的免疫反应性是由于肿瘤细胞本身的特性，而不是受体动物的作用。
Tumors induced in C3H and C57BL mice by benzopyrene elicited isograft immune reactions to tumor-specific antigens. The antigenicity of primary tumors was higher than that of the same sarcomas after a series of transfers through isologous hosts. Apparently the progressive growth of transplants of primary tumors is determined by the antigenicity of the tumors. Sarcomas that did not take in normal hosts—such as grafts of early transplant generations—grew progressively when transplanted to animals exposed to total-body X irradiation,i.e., in immunologically suppressed animals. The decrease in antigenicity was not associated with a complete loss of the tumor antigens. Tumors that could no longer immunize animals were still susceptible to the immune response elicited by immunogenic grafts of earlier transplant generations. Each of the 2 sarcomas produced in a single animal by 2 simultaneous applications of the carcinogen had distinct antigenic specificity. Tumors produced in a single animal may differ from each other in (a) transplantability, (b) immunogenicity, and (c) antigenic specificity. The exposure of preimmunized animals to X irradiation, followed by test grafting, was most useful for the analysis of antigenic specificity of non-transplantable tumors. Experiments in which sarcomas, originating in C3H, were tested for antigenicity in (C3H × C57BL)F1hybrids demonstrated that the lack of manifested immunological reactivity to certain tumors is due to the properties of the tumor cells themselves and not to the recipient animals.