Physiologic analysis of the myoclonus of Alzheimer's disease
Physiologic analysis of the myoclonus of Alzheimer's disease
复制标题
阿尔茨海默病肌阵挛的生理分析
DOI：
10.1212/wnl.34.7.898
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发表时间：
1984
期刊：
影响因子：
9.9
通讯作者：
N. Alvarez
中科院分区：
文献类型：
--
作者：
D. Wilkins;Mark Hallett;Alfredo Berardelli;T. Walshe;N. Alvarez
10例临床诊断为阿尔茨海默病的患者，包括3例21三体（唐氏综合征），发展为慢性肌阵挛性疾病。肌阵挛分析采用脑电活动急锁平均技术。7名受试者表现出一个局灶性，对侧中央，负脑电位的前因肌阵挛抽搐。该EEG事件不同于先前报告的与亚急性海绵状脑病（克雅氏病）的肌阵挛相关的事件。
Ten patients with clinically diagnosed Alzheimer's disease, including three cases of trisomy 21(Down's syndrome), developed a chronic myoclonic disorder. The technique of jerk-locked averaging of EEG activity wasused to analyze the myoclonus. Seven subjects demonstrated a focal, contralateral central, negative cerebral potential antecedent to the myoclonic jerks. This EEG event differs from that previously reported to be associated with the myoclonus of subacute spongiform encephalopathy (Creutzfeldt-Jakob disease).